Showing papers by "Harold W. Moore published in 1994"
49 citations
TL;DR: In this article, 4-Alkynyl-3-methoxy-4-hydroxycyclobutenones, a readily available class of compounds, cleave supercoiled DNA by a mechanism that appears to require at least some involvement of diradical intermediates formed in the ring expansion of the cyclobutenone.
Abstract: 4-Alkynyl-3-methoxy-4-hydroxycyclobutenones, a readily available class of compounds, cleave supercoiled DNA by a mechanism that appears to require at least some involvement of diradical intermediates formed in the ring expansion of the cyclobutenones
35 citations
TL;DR: In this article, a new synthetic route to highly substituted cyclobutenones is reported, which involves the 1,6-addition of both heteroatom-and carbon-based nucleophiles to 4,4-dimethoxy-3-ethenyl-2-methyl-cyclobuten-1-one (8) to give further functionalized cyclobutenedione monoketals.
Abstract: A new synthetic route to highly substituted cyclobutenones is reported. This involves the 1,6-addition of both heteroatom- and carbon-based nucleophiles to 4,4-dimethoxy-3-ethenyl-2-methyl-cyclobuten-1-one (8) to give further functionalized cyclobutenedione monoketals. These ketals function as precursors to quinones as illustrated by the synthesis of the natural benzofuranosesquiterpene 23
28 citations
TL;DR: In this paper, the total synthesis of indolizidine alkaloid,(±)-septicine (5 ) (27% overall yield) in 8 steps from dimethyl squarate was presented.
22 citations
TL;DR: In this article, a new synthetic route to highly substituted cyclobutenones is reported, which involves the 1,6-addition of both heteroatom-and carbon-based nucleophiles to 4,4-dimethoxy-3-ethenyl-2-methyl-cyclobuten-1-one (8) to give further functionalized cyclobutenedione monoketals.
Abstract: A new synthetic route to highly substituted cyclobutenones is reported. This involves the 1,6-addition of both heteroatom- and carbon-based nucleophiles to 4,4-dimethoxy-3-ethenyl-2-methyl-cyclobuten-1-one (8) to give further functionalized cyclobutenedione monoketals. These ketals function as precursors to quinones as illustrated by the synthesis of the natural benzofuranosesquiterpene 23