The role of glutathione redox imbalance in autism spectrum disorder: A review.

The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health.

Objective: Post-translational modifications of fibrinogen influence the occurrence and progression of thrombotic diseases. In this systematic review, we assessed the current literature on post-tran...

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Effects of Post-Translational Modifications of Fibrinogen on Clot Formation, Clot Structure, and Fibrinolysis: A Systematic Review.

High-voltage direct current (HVDC) lines are the technology of choice for the transport of large amounts of energy over long distances. The operation of these lines produces static electric fields (EF), but the data reviewed in previous assessments were not sufficient to assess the need for any environmental limit. The aim of this systematic review was to update the current state of research and to evaluate biological effects of static EF. Using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) recommendations, we collected and evaluated experimental and epidemiological studies examining biological effects of exposure to static EF in humans (n = 8) and vertebrates (n = 40). There is good evidence that humans and animals are able to perceive the presence of static EF at sufficiently high levels. Hair movements caused by electrostatic forces may play a major role in this perception. A large number of studies reported responses of animals (e.g., altered metabolic, immunologic or developmental parameters) to a broad range of static EF strengths as well, but these responses are likely secondary physiological responses to sensory stimulation. Furthermore, the quality of many of the studies reporting physiological responses is poor, which raises concerns about confounding.
 The weight of the evidence from the literature reviewed did not indicate that static EF have adverse biological effects in humans or animals. The evidence strongly supported the role of superficial sensory stimulation of hair and skin as the basis for perception of the field, as well as reported indirect behavioral and physiological responses. Physical considerations also preclude any direct effect of static EF on internal physiology, and reports that some physiological processes are affected in minor ways may be explained by other factors. While this literature does not support a level of concern about biological effects of exposure to static EF, the conditions that affect thresholds for human detection and possible annoyance at suprathreshold levels should be investigated.

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Biological effects of exposure to static electric fields in humans and vertebrates: a systematic review

Structural characterization of phosphorylated Pleurotus ostreatus polysaccharide and its hepatoprotective effect on carbon tetrachloride-induced liver injury in mice

A certain role of SOD/CAT imbalance in pathogenesis of autism spectrum disorders.

The external static electric field (SEF) of man-made origin brings to the substantially increased SEF background in a human environment the biological activity of which is a moot question. The paper reports on rats blood plasma/serum proteome modifications by means of 1D polyacrilamide gel electrophoresis and clotting process alterations after the short- and long-term SEF exposures of 200 kV/m. The results indicate decrease of fast α1 and α2 globular proteins in plasma coinciding with clotting acceleration after the short-term SEF, and attenuation of clotting-dependent proteome modifications reflected with incomplete coagulation after the long-term SEF exposure. Increased lysozyme activity in serum unlike plasma was observed after both SEF exposures. Applied model of the high-voltage SEF environment indicates dependence of biological systems functioning on the external SEF.

Biological effects of static electric field: Plasma/serum proteome analysis of rats.

Alfa2-adrenoblockers attenuate the elevated plasma cholesterol, anxiety levels and restore impaired spatial memory of rats under the chronic noise exposure.

It was hypothesized that the biological activity of external electrostatic fields is a result of field-induced physical processes on the cell membrane. Membrane is a dynamic lipoprotein structure and even the marginal changes of its physical parameters will be reflected on the structural and functional state of bilayer. For revealing the possible changes, the lipidprotein interactions in rat erythrocyte membranes after the in vivo chronic influence (6 days, 6 hours per day) of 200 kV/m electrostatic field were investigated. The biophysical parameters of erythrocyte ghosts were investigated by spectrofluorimetric method using the fluorescent probes 1-anilinonaftalene-8-sulfonate and pyrene. Oxidative modifications of membrane components were investigated also. The data obtained established that the field influence leads to the redistribution of membrane surface charge. It increases the immersion degree of the peripheral proteins in lipid bilayer and, in all probability, induces the conformational alterations of membrane integral proteins. These changes can be induced by the direct influence of field on the membranes and/or they can be a result of the field-generated changes in metabolic cascades. Our results emphasize the importance of membrane proteins in realization of the effect of electrostatic field.

http://www.ijsrpub.com/uploads/papers/IJSRES/2015/mar/IJSRES-14-117.pdf

Biological Activity of External Electrostatic Field Exceeding the Natural Background: Erythrocyte Plasma Membrane Target

The aim of this study was to determine activities of pro-/antioxidant enzymes, reactive oxygen species (ROS) content, and oxidative modification of proteins and lipids in red blood cells (RBCs) and blood plasma of rats exposed to electrostatic field (200 kV/m) during the short (1 h) and the long periods (6 day, 6 h daily). Short-term exposure was characterized by the increase of oxidatively damaged proteins in blood of rats. This was strongly expressed in RBC membranes. After long-term action, RBC content in peripheral blood was higher than in control (P < 0.01) and the attenuation of prooxidant processes was shown.

Hayk Harutyunyan

Papers

A certain role of SOD/CAT imbalance in pathogenesis of autism spectrum disorders.

Biological effects of static electric field: Plasma/serum proteome analysis of rats.

Alfa2-adrenoblockers attenuate the elevated plasma cholesterol, anxiety levels and restore impaired spatial memory of rats under the chronic noise exposure.

Biological Activity of External Electrostatic Field Exceeding the Natural Background: Erythrocyte Plasma Membrane Target

Biological effects of the electrostatic field: red blood cell-related alterations of oxidative processes in blood