H
Hazel Lum
Researcher at Wenzhou Medical College
Publications - 48
Citations - 4188
Hazel Lum is an academic researcher from Wenzhou Medical College. The author has contributed to research in topics: Endothelial stem cell & Protein kinase C. The author has an hindex of 29, co-authored 48 publications receiving 3905 citations. Previous affiliations of Hazel Lum include University of Illinois at Chicago & Centre national de la recherche scientifique.
Papers
More filters
Journal ArticleDOI
Oxidant stress and endothelial cell dysfunction.
Hazel Lum,Kenneth A. Roebuck +1 more
TL;DR: Recent findings on the cellular and molecular mechanisms by which ROS signal events leading to impairment of endothelial barrier function and promotion of leukocyte adhesion are discussed.
Journal ArticleDOI
Regulation of vascular endothelial barrier function
Hazel Lum,Asrar B. Malik +1 more
TL;DR: Current research is in the identification of protein substrates of PKC isozymes, the specific role of their phosphorylation in barrier function, and determining the precise role of MLCK in modulation of endothelial barrier function.
Journal ArticleDOI
Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism.
Yong Chool Boo,Jinah Hwang,Michelle C. Sykes,Belinda J. Michell,Bruce E. Kemp,Hazel Lum,Hanjoong Jo +6 more
TL;DR: The results suggest that shear stress stimulates eNOS by two different mechanisms: 1) PKA- and PI3K-dependent and 2) Pka-dependent but PI3k-independent pathways.
Journal ArticleDOI
Mechanisms of increased endothelial permeability.
Hazel Lum,Asrar B. Malik +1 more
TL;DR: The increase in endothelial permeability in response to inflammatory mediators such as thrombin and histamine is accompanied by reversible cell rounding and interendothelial gap formation, suggesting that the predominant transport pathway is a diffusive one (i.e., via cellular junctions (paracellular transport)).
Journal ArticleDOI
6-Hydroxydopamine-induced alterations in blood-brain barrier permeability.
Paul M. Carvey,C.H. Zhao,Bill Hendey,Hazel Lum,J. Trachtenberg,B.S. Desai,Joshua A. Snyder,Yuangui Zhu,Zaodung Ling +8 more
TL;DR: Assessment of BBB integrity by examining the leakage of FITC‐labeled albumin or horseradish peroxidase from the vasculature into parenchyma in animals exposed to the DA neurotoxin 6‐hydroxydopamine (6OHDA) suggests that the events associated with DA neuron loss compromise BBB function.