Hee Jeong Park

TL;DR: It is shown that patterns of mutation acquisition, persistence, and clearance vary but have a number of interesting correlations with clinical outcomes, and clinical implications of mutation profiles and dynamics in CML should be interpreted with caution.

TL;DR: Overall, it is demonstrated that distinct categories of genetic lesions play roles at different stages of sAML in a generally fixed order.

TL;DR: The recently recommended genomic classification is an appropriate and replicable categorization system in the NK AML population, and the subgroup of AML with mutated chromatin, RNA-splicing genes, or both showed extremely poor survival in NK-AML; thus, a novel approach is needed to improve their prognosis.

TL;DR: There was no significant difference in overall survival, event-free survival, and relapse risk according to TET2mut or IDH1/2mut, and no significant association between the categories of 5hmC levels and survival or relapse risk (all p>0.05).

TL;DR: Clonal evolution patterns can be postulated based on the acquisition/expansion of mutations related to the three signature pathways in acute myelodysplasia using whole-exome sequencing and targeted deep sequencing on serial samples.