H
Helen M Fernandes
Researcher at University of Cambridge
Publications - 34
Citations - 2556
Helen M Fernandes is an academic researcher from University of Cambridge. The author has contributed to research in topics: Randomized controlled trial & Intracerebral hemorrhage. The author has an hindex of 15, co-authored 34 publications receiving 2317 citations. Previous affiliations of Helen M Fernandes include Newcastle University & Boston Children's Hospital.
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Journal ArticleDOI
Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial
A. David Mendelow,Barbara A. Gregson,Helen M Fernandes,Gordon D Murray,Graham M. Teasdale,D Terence Hope,Abbas Karimi,M Donald M Shaw,David Barer +8 more
TL;DR: Patients with spontaneous supratentorial intracerebral haemorrhage in neurosurgical units show no overall benefit from early surgery when compared with initial conservative treatment.
Journal ArticleDOI
Surgery in Intracerebral Hemorrhage The Uncertainty Continues
TL;DR: This meta-analysis suggests a benefit from surgery, with a reduction in the chances of death and dependency after surgical treatment by a factor of 0.63, when meta- analysis is restricted to modern-day, post-CT, well-constructed, balanced trials.
Journal ArticleDOI
Design and analysis of phase III trials with ordered outcome scales: the concept of the sliding dichotomy
Gordon D Murray,David Barer,Sung C. Choi,Helen M Fernandes,Barbara A. Gregson,Kennedy R. Lees,Andrew I R Maas,A Marmarou,AD Mendelow,Ewout W. Steyerberg,Gillian S. Taylor,G. M. Teasdale,Christopher J. Weir +12 more
TL;DR: The proposed alternative approach where a favorable outcome is defined as better than would be expected, taking account of each individual patient's baseline prognosis is illustrated through a worked example based on data from a Phase III trial in head injury.
Journal ArticleDOI
Reversible ischemia around intracerebral hemorrhage: a single-photon emission computerized tomography study.
M. Shahid Siddique,Helen M Fernandes,Thomas D Wooldridge,John D Fenwick,Piotr J. Slomka,A. David Mendelow +5 more
TL;DR: This is the first study in which it is documented that some of the perilesional hypoperfused tissue around human ICH regains its perfusion in the long term, leading the authors to suggest that there may be a penumbra in human I CH.