Showing papers by "Helen Roberts published in 1994"

Recovery of bone density in women who stop using medroxyprogesterone acetate.

Abstract: Depot medroxyprogesterone acetate works as a contraceptive by inhibiting the secretion of pituitary gonadotrophin and thus suppressing ovulation. Women who use it are partially oestrogen deficient, and we have previously shown that long term users have reduced bone density.1 In this study we investigated whether such bone loss is reversible. We recruited 54 women (50 of European origin, four of Maori origin. Group 1 comprised 14 women who had used depot medroxyprogesterone acetate for at least three years; they were studied while taking the drug and after having stopped it. Group 2 comprised 22 long term users of the drug, who were studied while they were taking it. The control group, group 3, comprised 18 women who had never used the drug. The age range in the groups was similar, but a higher proportion of women who had ever …