H
Helen Turley
Researcher at University of Oxford
Publications - 141
Citations - 17417
Helen Turley is an academic researcher from University of Oxford. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor. The author has an hindex of 65, co-authored 141 publications receiving 16466 citations. Previous affiliations of Helen Turley include John Radcliffe Hospital & Russian Academy.
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Journal Article
Hypoxia-inducible Expression of Tumor-associated Carbonic Anhydrases
Charles C. Wykoff,Nigel J. P. Beasley,Peter H. Watson,Kevin Turner,Jaromir Pastorek,Amen Sibtain,George S. Wilson,Helen Turley,Kate L. Talks,Patrick H. Maxwell,Christopher W. Pugh,Peter J. Ratcliffe,Adrian L. Harris +12 more
TL;DR: A new class of HIF-1-responsive gene is defined, the activation of which has implications for the understanding of hypoxic tumor metabolism and which may provide endogenous markers for tumor hypoxia.
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The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
Kate L. Talks,Helen Turley,Kevin C. Gatter,Patrick H. Maxwell,Christopher W. Pugh,Peter J. Ratcliffe,Adrian L. Harris +6 more
TL;DR: In the majority of solid tumors examined, including bladder, brain, breast, colon, ovarian, pancreatic, prostate, and renal carcinomas, nuclear expression of HIF-1α and -2α was observed in varying subsets of the tumor cells.
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Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor *
Rebecca J. Appelhoff,Ya-Min Tian,Raju R. Raval,Helen Turley,Adrian L. Harris,Christopher W. Pugh,Peter J. Ratcliffe,Jonathan M. Gleadle +7 more
TL;DR: It is shown using suppression by small interference RNA that each of the three PHD isoforms contributes in a non-redundant manner to the regulation of both Hif-1α and HIF-2α subunits and that the contribution of each PHD under particular culture conditions is strongly dependent on the abundance of the enzyme.
Journal ArticleDOI
bcl-2 Protein in Non-Small-Cell Lung Carcinoma
Francesco Pezzella,Helen Turley,Isinzu Kuzu,Mohammed Fahim Tungekar,Michael S. Dunnill,Chris B. Pierce,Adrian L. Harris,Kevin C. Gatter,David Y. Mason +8 more
TL;DR: The proto-oncogene bcl-2 is abnormally expressed in some lung carcinomas, and its expression may have prognostic importance.
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Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
Alexandra Giatromanolaki,M I Koukourakis,Efthimios Sivridis,Helen Turley,Kate L. Talks,Francesco Pezzella,K C Gatter,Adrian L. Harris +7 more
TL;DR: It is concluded that HIF1α and HIF2α overexpression is a common event in NSCLC, which is related to the up-regulation of various angiogenic factors and with poor prognosis.