Helena W. Morrison

TL;DR: Quantitative analysis reveals a significant spatiotemporal relationship between microglia morphology and evolving cerebral injury in the ipsilateral hemisphere after IS and reperfusion and illustrates that microglian activation after stroke includes both increased and decreased cell ramification.

TL;DR: The skeleton analysis protocol described herein is well suited for a regional analysis of multiple microglia within an entire photomicrograph or region of interest (ROI) whereas FracLac provides a complementary individual cell analysis.

TL;DR: Mechanisms implicating astrocytes in NVC-mediated vascular responses, limitations encountered as a result of the challenges in maintaining all the constituents of the neurovascular unit intact and deliberate current controversial findings disputing a main role for astracytes are discussed.

TL;DR: The spatiotemporal changes in microglia morphology over 28 days following rat midline fluid percussion injury (mFPI) likely reflect altered physiology with diverse and widespread impact on neuronal and circuit function.

TL;DR: It is posited that a sex difference in the presence of constitutive CD11b has a role in determining male and female microglia phagocytic responses to ischemia and these findings are critical to understanding potential sex differences in glial physiology as well as stroke pathobiology which are foundational for the development of future sex-specific stroke therapies.