Hem R. Gurung

TL;DR: It is suggested to target IL-6 and TNF-α as additional proangiogenic factors in the cornea during the development of herpetic stromal keratitis as a means to alleviate further neovascularization and tissue pathology associated with the host immune response to the pathogen.

TL;DR: It is reported that cornea infiltrating leukocytes including neutrophils and T cells do not have a significant role in corneal neovascularization past virus clearance and neutralization of FGF-2 had a more pronounced effect on the suppression of neov vascularization in a time-dependent, leukocyte-independent manner.

TL;DR: Overall, 0ΔNLS affords remarkable protection against HSV-1-associated ocular sequelae by impeding viral replication, dissemination, and establishment of latency, which underscores the necessity to reconsider strategies that utilize attenuated live virus as opposed to subunit vaccines against ocular HSV -1 infection.

TL;DR: The results suggest infiltrated macrophages are early effectors in the nerve regression following HSV-1 infection, and propose the neurodegeneration mechanism involves macrophage, local up-regulation of IL-6, and activation of STAT3.

TL;DR: It is shown that a live-attenuated HSV-1 vaccine elicits humoral immune responses that are unparalleled by a glycoprotein subunit vaccine vis-à-vis Ab persistence and host protection, and this findings establish a novel mechanism of humoral protection in the eye involving FcRn.