Showing papers by "Henry Eyring published in 1977"

Men, Mines, and Molecules

Abstract: My ancestors were drawn together from northern Europe by the new Mormon religion. My mother's people, the Romneys and Cottams, migrated from around Preston, England, arriving in Nauvoo, Illinois in 1839. My grandfather, Henry Eyring, came from Cohurg in Germany, and Grandmother Eyring came from German Switzerland. My Eyring grandparents met while crossing the plains and arrived in Salt Lake City in the same pioneer company in the fall of 1860. My mother's people had reached Salt Lake City 10 years earlier. During the next three decades, colonization of the intermountain area spread from Salt Lake City to Alberta on the North and to Chihuahua and Sonora on the South, wherever the water could be turned out onto the parched land. As a result of these migrations, all my grandparents ended up in the late 1880s in Colonia, Juarez, in northern Mexico, about 100 miles straight south of Columbus, New Mexico.

Conformational basis for the activation of adenylate cyclase by adenosine

Abstract: The ability of adenosine to stimulate adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] and increase adenosine 3′:5′-cyclic monophosphate (cAMP) levels has important biochemical consequences. These include the suppression of immune responses and cardiovascular effects. Recent investigations involving the ability of adenosine and adenosine analogs to stimulate adenylate cyclase provided experimental data that appear to be correlated with the ability of adenosine and analogs of adenosine to exist in the glycosidic high anti conformation. 9-β-D-Arabinofuranosyladenine, which is not stable in the high anti conformation, is inactive as a stimulator of adenylate cyclase. 2′-Deoxyadenosine is also not stable in the high anti conformation but its instability may be significantly decreased by intramolecular adjustments promoted by receptor or active site interactions. 2′-Deoxyadenosine does not activate adenylate cyclase in lymphocytes when ATP is the substrate but is able to activate adenylate cyclase when 2-fluoro ATP is the substrate. The inability of certain analogs of adenosine, with bulky groups substituted for hydrogen at the 8 position of the adenine base, to activate adenylate cyclase and increase either lymphocyte or cardiac cell cAMP levels is consistent with the designation of the high anti conformation as being the conformation required for the activation of adenylate cyclase. An understanding of the glycosidic conformation required by the extracellular adenosine receptor of the adenosine molecule provides the basis for designing nucleoside analogs of adenosine that will exert a desired effect on cAMP levels. The avoidance of unwanted immunosuppressive or cardiotoxic effects can be arranged by structural changes that prohibit the high anti conformation.

A theoretical investigation of symmetry‐forbidden transitions in magnetic circular dichroism and electronic spectra of benzene

Abstract: In this paper, the vibronic coupling calculation in the π‐electron framework has been carried out for 〈B2u‖?′vc‖E1u〉, 〈A1g‖?′vc‖B2u〉, and 〈B1u‖?′vc‖E1u〉 of benzene by using the so‐called linear displacement method. Our method differs from that of Liehr’s by the fact that in our calculation all multicenter integrals have been evaluated exactly. The vibronic coupling matrix elements obtained have then been applied to calculate the magnetic rotational strengths and dipole strengths of symmetry‐forbidden transitions 1A1g→1B1u and 1A1g→1B2u and the electronic matrix elements involved in radiationless transitions. It is well known that the 1A1g→1B2u transition is symmetry‐forbidden in MCD and uv spectra and becomes allowed through the mixing of both B1u and B2u states with the E1u state through the E2g modes of vibration. We have developed a method for determining the dipole strengths and magnetic rotational strengths associated with each individual E2g promoting mode from the experimental MCD and uv spectra. T...

Reversible and irreversible inhibition by anesthetics of the calcium-induced luminescence of aequorin

Abstract: The actions of various kinds of so-called membrane-stabilizing drugs on Ca2+-induced flash intensity of purified aequorin, a photoprotein obtained from Aequorea aequorea, were examined. All drugs used in this experiment, including inhalational anesthetics, tetracaine, chlorpromazine, and morphine, depressed flash intensity, and the inhibition increased with time. The inhibition followed a mixture of reversible and irreversible kinetics. A method of analyzing irreversible kinetics is presented. The dissociation constants for reversible inhibition and the rate constants for irreversible inhibition are presented for each agent.

Effects of Oxygen on the Mechanism of Cadmium Dissolution in Sulfate Solutions

Abstract: Die Losungsgeschwindigkeit von Cd in sauren Sulfat-Losunge-n (gemessen unter potentiostatischen Bedingungen) ist bei gegebenem Potential in Og-gesattigten Losungen groser, als in N2-gesattigten

Significant structure theory applied to phase separation.

Abstract: The significant structure theory of liquids has been applied to the partially miscible system of the O3-O2 mixture, which exhibits partial miscibility in the temperature range from -195.5°C to -179.9°C. The thermodynamic condition for phase separation is given by the following inequality: [Formula: see text] A partition function for the binary liquid mixture is developed using significant liquid structure theory. Here Xi is the mole fraction of either of the two components. We obtain the coexistence curve of the O3-O2 system by varying the mole fractions of the components to find the temperature at which the two liquids separate. The agreement between theory and experiment is satisfactory.

Significant structure theory applied to liquid helium-3.

Abstract: The significant structure theory of liquids is successfully applied to the quantum liquid 3He. The partition function uses the Debye partition function for the solid-like molecules and the Fermi-Dirac partition function for the gas-like degrees of freedom. To evaluate the gas-like partition function, numerical calculations are performed and some integral functions appearing in the equation of state of the ideal Fermi-Dirac gas are tabulated. In the solid-like molecules, the molar volume Vs depends on the temperature, and a linear dependence is used. The thermodynamic properties, such as molar volume, vapor pressure, entropy, heat capacity, and the critical constants as well as the surface tension of liquid 3He are calculated. The agreement between theory and experiment is satisfactory.

Single partition function for three phases

Abstract: The significant structures theory of liquids has been extended to take into account (i) translational degrees of freedom in the degeneracy term and (ii) the perturbation term which becomes important near the critical region. With these improvements, the calculated thermodynamic properties of argon agree very well with experimental results from the melting point through the critical point, along the coexistence curve as well as along the critical isochore and for the solid and the vapor.

Effects of oxygen on the mechanism of cadmium dissolution in sulfate solutions

Abstract: Die Losungsgeschwindigkeit von Cd in sauren Sulfat-Losunge-n (gemessen unter potentiostatischen Bedingungen) ist bei gegebenem Potential in Og-gesattigten Losungen groser, als in N2-gesattigten.