H
Henry F. Vischer
Researcher at VU University Amsterdam
Publications - 115
Citations - 4093
Henry F. Vischer is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 36, co-authored 105 publications receiving 3701 citations. Previous affiliations of Henry F. Vischer include Centre national de la recherche scientifique & Utrecht University.
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Journal ArticleDOI
Pharmacological modulation of chemokine receptor function
Danny J. Scholten,Meritxell Canals,David Maussang,Luc Roumen,Martine J. Smit,Maikel Wijtmans,C de Graaf,Henry F. Vischer,Rob Leurs +8 more
TL;DR: An overview of the evidence supporting modulation of this intriguing receptor family by a range of ligands, including small molecules, peptides and antibodies is given.
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Crystal structure-based virtual screening for novel fragment-like ligands of the human histamine H1 receptor
Chris de Graaf,Albert J. Kooistra,Henry F. Vischer,Vsevolod Katritch,Martien Kuijer,Mitsunori Shiroishi,So Iwata,Tatsuro Shimamura,Raymond C. Stevens,Iwan J. P. de Esch,Rob Leurs +10 more
TL;DR: The optimized in silico screening approach was successfully applied to identify a chemically diverse set of novel fragment-like H(1)R ligands with an exceptionally high hit rate, 73%.
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Pharmacogenomic and Structural Analysis of Constitutive G Protein–Coupled Receptor Activity
Martine J. Smit,Henry F. Vischer,Remko A. Bakker,Aldo Jongejan,Henk Timmerman,Leonardo Pardo,Rob Leurs +6 more
TL;DR: A brief historical introduction to the concept of constitutive receptor activity and the pharmacogenomic and structural aspects of constitutively active GPCR activity is provided.
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Discrepancy Between Molecular Structure and Ligand Selectivity of a Testicular Follicle-Stimulating Hormone Receptor of the African Catfish (Clarias gariepinus)
Jan Bogerd,Marion Blomenröhr,Eva Andersson,H. H. A. G. M. Van Der Putten,Cornelis P. Tensen,Henry F. Vischer,Joke C.M. Granneman,Coby Janssen-Dommerholt,H.J.Th. Goos,Rüdiger W. Schulz +9 more
TL;DR: It is concluded that the cloned cDNA encoding a functional FSH-R from African catfish testis appears to be less discriminatory for its species-specific LH than its avian and mammalian counterparts.
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Gonadotropins, their receptors, and the regulation of testicular functions in fish.
Rüdiger W. Schulz,Henry F. Vischer,José E. Cavaco,Eduarda M. Santos,Charles R. Tyler,H.J.Th. Goos,Jan Bogerd +6 more
TL;DR: It is found that there is no indication in adult male African catfish for a direct, GnRH-mediated stimulation of LH synthesis, and the role of GnRH as LH secretagogue is evident, but the limited available information at present precludes a generalized view on the testicular feedback on FSH.