Rob Leurs

TL;DR: Northern blot and in situ hybridization analyses showed the 5-HT7 transcripts to be expressed in discrete areas of the limbic brain (e.g., pyramidal hippocampus cells, tenia tecta, amygdaloid, or mammillary nuclei), suggesting that the receptor mediates serotoninergic controls in functions like mood, learning, or neuroendocrine and vegetative behaviors.

TL;DR: The H3R is an autoreceptor and heteroreceptor providing negative feedback on histaminergic and inhibition on other neurons, a block of these actions promotes waking and the development of anti-inflammatory drugs is anticipated.

TL;DR: The description of pharmacological tools for the H1, H2 and H3 receptor, including the recent cloning of the receptor genes, and their respective signal transduction mechanisms are described.

TL;DR: A review of the available H3 receptor agonists and antagonists and their effects in a variety of pharmacological models in vitro and in vivo can be found in this paper, where the possible therapeutic applications of the various compounds are discussed.

TL;DR: The identification of these new H3 receptor isoforms and their specific signaling properties adds a new level of complexity to the understanding of the role of histamine, and the H3 receptors in brain function.