Showing papers by "Herbert M. Lachman published in 1992"

TL;DR: It is found that acute treatment with lithium, resulting in serum levels that are within the therapeutic range effective in patients with mood disorders, significantly enhances basal expression of the NPY gene in rat hippocampus, which supports the hypothesis that gene expression may be an important target of lithium's therapeutic action.

TL;DR: It is found that NLH rats have approximately a 30-35% decrease in basal hippocampal NPY mRNA compared with SD and LH rats, and the regulation of NPY gene expression may be involved in the reduced vulnerability of NLH Rats to develop learned helplessness.