Cancer begins as a nearby sickness, yet it can metastasize to the lymph hubs and far off organs. At essential finding, prognostic markers are utilized to survey whether the move to systemic illness is probably going to have happened. The overall model of metastasis mirrors this view - it recommends that metastatic limit is a late, obtained occasion in tumourigenesis. Others have proposed the possibility that breast tumour is inherently a systemic sickness. New atomic advancements, for example, DNA microarrays, bolster metastatic limit may be an innate component of breast tumours. This information has critical ramifications for visualization predicition and our comprehension of metastasis.

/pdf/biomarkers-role-in-breast-cancer-treatment-a-review-4phy89c2lw.pdf

Biomarkers Role in Breast Cancer Treatment-A Review

Oncology nurses’ knowledge about exploring chemotherapy related - Extravasation care: A cross-sectional study

Adverse drug reactions responses are because of the use of anticancer medications are an overall issue and can't be neglected. Adverse drug reactions can range from nausea, vomiting or any other mild reaction to severe myelosuppression. ADRs are most basic purposes behind morbidity and mortality and expansion the monetary burden on patient and society. Via cautious ADR checking, their frequency can be diminished

/pdf/review-on-adverse-drug-reactions-of-chemotherapy-drugs-rw1m1dgi7v.pdf

Review on: Adverse Drug Reactions of Chemotherapy Drugs

Background Impaired brow function in adult patients with arteriovenous malformation is a serious disability that can even influence the field of vision. Brow reanimation techniques are used to recover a more natural appearance and brow function. Many static procedures have been set to augment brow elevation, but only dynamic procedures can lead to better functional results. In this study, the experience of a single surgeon addressing the challenge of brow restoration with dynamic procedures is presented. Methods A retrospective review was performed using the records of 4 adult patients who underwent dynamic procedures using a soft tissue expander for brow restoration after arteriovenous malformation excision in the unilateral site of the forehead with the expander on the contralateral side. Movement and electrodiagnostic examinations were performed postoperatively at 2 months. Results The patients included 3 males and 1 female (mean age, 20.5 ± 4.04 years). Brow improvement was noted in all patients. The results of the electrodiagnostic examination showed synchronous and spontaneous motor unit potentials and compound muscle action potentials with the contralateral forehead. Conclusions Dynamic procedures using a soft tissue expander can provide both static and dynamic functional brow elevation of the contralateral frontalis and skin.

Dynamic Brow Restoration Using a Soft Tissue Expander in Adult Patients With Arteriovenous Malformation.

Introduction  : Les pseudotumeurs inflammatoires sont un groupe rare de tumeurs benignes d’etiologie inconnue. La localisation cervico-faciale est rare, particulierement au niveau des sinus para-nasaux. Les auteurs rapportent une nouvelle observation de pseudotumeur inflammatoire au niveau du sinus maxillaire et discutent les caracteristiques cliniques et therapeutiques de cette entite en se basant sur une revue de la litterature. Observation  : Patiente, âgee de 31 ans, ayant consulte pour une tumefaction jugale droite evoluant depuis trois mois. L’examen clinique a montre un comblement vestibulaire superieur droit avec une mobilite des dents en regard. La tomodensitometrie a confirme la presence d’un processus tissulaire dense du sinus maxillaire droit avec erosion des parois osseuses et extension a la fosse nasale homolaterale. Elle a beneficie d’une exerese tumorale. L’examen histologique a ete en faveur d’une tumeur myofibroblastique inflammatoire du sinus maxillaire. Aucune recidive n’a ete notee avec un recul de neuf ans. Discussion  : Bien que benignes, ces pseudotumeurs inflammatoires presentent des caracteristiques cliniques d’agressivite avec un pouvoir lytique mimant une tumeur maligne. Le traitement de ces tumeurs est mal codifie. L’exerese chirurgicale et les corticosteroides representent les modalites therapeutiques les plus utilisees.

Pseudotumeur inflammatoire du sinus maxillaire : un cas

Les tumeurs benignes de la cavite buccale representent toutes les neoformations histologiquement benignes ou de benignite relative se developpant a partir des elements constitutifs de la muqueuse buccale. Ces lesions sont reparties cliniquement selon leur aspect macroscopique, mais leur diagnostic reste histologique et leur classification depend de la nature des tissus qui les composent. Leurs etiologies sont diverses et dominees par la mauvaise hygiene buccodentaire, la consommation de tabac et par certaines infections virales. Leur frequence est elevee mais reste difficile a apprecier; pres d’un tiers de la population serait concerne. En dehors d’etudes ciblant des populations bien specifiques, peu de publications se sont penchees sur une etude epidemiologique dans la population generale. Ce travail a pour but d’evaluer la frequence, la nature et les facteurs predisposants des tumeurs benignes de la cavite buccale dans une population aleatoire.

/pdf/tumeurs-benignes-de-la-cavite-buccale-etude-retrospective-de-44gx74heux.pdf

Tumeurs bénignes de la cavité buccale : étude rétrospective de 209 cas

Hay-Wells syndrome is a rare form of ectodermal dysplasia. We report a case of a 5-year-old girl, the daughter of non-consanguineous parents. She had the characteristic of facial dysmorphia of Hay-Wells syndrome. Molecular analysis confirmed diagnosis. The patient had a cleft palate, which is considered one of cardinal signs of this syndrome. She underwent Veau-Wardill-Kilner palatoplasty with satisfactory results. Through this case report, we describe the maxillofacial manifestations of this syndrome with a literature review.

Syndrome de Hay-Wells : à propos d’un cas

Complications of chemotherapy stem from the toxicity of products used and complications related to the modes and routes of administration of these products. To minimize the risks associated with the latter, due to the toxicity of the drugs administered and the long duration of treatment requiring repeated access to the venous system, the use of implantable venous access port is recommended for the administration of these products. However, this does not exclude the risk of complication occurrence such as extravasation of cytotoxic drugs. Passage in extravascular areas of chemotherapy drugs is a relatively less frequent incident but may lead to injury up to the extensive tissue necrosis that can worsen the patient's prognosis and alter his functional life comfort. Although this complication is very well known and widely described in literature, very few cases have been reported hence the interest of this case report.

https://www.longdom.org/open-access/extended-arm-necrosis-by-chemotherapy-drugs-extravasation-2167-7700-1000147.pdf

Extended Arm Necrosis by Chemotherapy Drugs Extravasation

L’histiocytose langerhansienne est une maladie proliferative non maligne, qui interesse les cellules dendritiques de Langerhans. Il s’agit d’une maladie orpheline touchant essentiellement l’enfant et l’adulte jeune. Son etiologie reste encore inconnue, son spectre clinique est assez large. Nous rapportons un cas clinique d’histiocytose langerhansienne osseuse multifocale chez un jeune adulte de 25 ans ayant touche initialement le rachis, et secondairement la mandibule et le crâne. Le diagnostic fut confirme par l’examen histologique. L’evolution fut favorable apres un traitement chirurgical non agressif. A partir de cette observation, nous ferons une revue de la litterature pour mettre le point sur les aspects cliniques, histologiques, radiologiques, therapeutiques et evolutifs de cette maladie orpheline

https://aos.edp-dentaire.fr/articles/aos/pdf/2012/02/aos2012258p127.pdf

Hicham Sabani

Papers

Tumeurs bénignes de la cavité buccale : étude rétrospective de 209 cas

Syndrome de Hay-Wells : à propos d’un cas

Extended Arm Necrosis by Chemotherapy Drugs Extravasation

Histiocytose langerhansienne osseuse multifocale. À propos d’un cas

Lymphangiectasies pseudocondylomateuses de la vulve