A compound having Formula (I) or a pharmaceutically acceptable salt thereof, wherein X, R1 and R2 are defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.

Pyrimidinones as casein kinase II (CK2) modulators

A compound according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R6, R7 and Z are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.

Pyrazolo-pyrimidines as casein kinase ii (ck2) modulators

PURPOSE: To obtain a new compound capable of exhibiting remarkable enzyme- inhibiting activity against casein kinase II and useful as an antitumor agent. CONSTITUTION: A compound of the formula or its salt. This compound is obtained by inoculating a microorganism belonging to the genus Pseudorobillarda sp. or its variant (FERM P-13325), e.g. Pseudobillarda sp. F26668 into a nutrient source-containing medium and culturing the microorganism under aerobic conditions, harvesting the cultured mixture from the bacterial cell by normal separation means and separating and purifying the cultured product. Properties of the compound of the formula: Appearance, pale yellow solid; molecular formula, C 13 H 10 O 5 ; solubility, readily soluble in acetone, methanol and ethyl acetate and sparingly soluble in chloroform and water and insoluble in hexane; discrimination of acidic, neutral or basic substance, acidic substance; Rf value, 0.43 (using 'Kiesel gel 60F 254 (R)' manufactured by Merck & Co., Inc. and developed using chloroform/methanol); color reaction, positive to iodine reaction and molybdophosphoric acid reaction and negative to ninhydrin reaction. COPYRIGHT: (C)1994,JPO

Hidetoshi Ogino

Papers

Antitumor substance be-26668 and its production