H
Hirokuni Takano
Researcher at Jikei University School of Medicine
Publications - 44
Citations - 1165
Hirokuni Takano is an academic researcher from Jikei University School of Medicine. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 13, co-authored 38 publications receiving 941 citations. Previous affiliations of Hirokuni Takano include University of California, San Francisco.
Papers
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Journal ArticleDOI
Amplification of PVT1 Contributes to the Pathophysiology of Ovarian and Breast Cancer
Yinghui Guan,Wen Lin Kuo,Jackie L. Stilwell,Hirokuni Takano,Anna Lapuk,Jane Fridlyand,Jian-Hua Mao,Mamie Yu,Melinda A. Miller,Jennifer Santos,Steve E. Kalloger,Joseph W. Carlson,David G. Ginzinger,Susan E. Celniker,Gordon B. Mills,David G. Huntsman,Joe W. Gray +16 more
TL;DR: The results suggest that MYC and PVT1 contribute independently to ovarian and breast pathogenesis when overexpressed because of genomic abnormalities, and suggest that PVT 1-mediated inhibition of apoptosis may explain why amplification of 8q24 is associated with reduced survival duration in patients treated with agents that act through apoptotic mechanisms.
Journal ArticleDOI
Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma.
Angela Bik Yu Hui,Yvonne Y. Y. Or,Hirokuni Takano,Raymond K. Y. Tsang,Ka Fai To,Xin Yuen Guan,Jonathan S.T. Sham,Katherine Wing Ki Hung,Cleo N.Y. Lam,Charles Andrew van Hasselt,Wen Lin Kuo,Joe W. Gray,Dolly P. Huang,Kwok Wai Lo +13 more
TL;DR: The findings suggest that cyclin D1 is a target oncogene at 11q13 in nasopharyngeal carcinoma and its activation plays a significant role in nasolympic carcinoma tumorigenesis.
Journal Article
Deletion mapping of chromosome 3p in human uterine cervical cancer.
Takashi Kohno,Takayama H,Masaaki Hamaguchi,Hirokuni Takano,Naohito Yamaguchi,Hitoshi Tsuda,Setsuo Hirohashi,Henrik Vissing,Shimizu M,Mitsuo Oshimura +9 more
TL;DR: This result indicates the presence of a novel tumor-suppressor gene in the region of 3p13-p21.1, which is involved in the development of several human cancers.
Journal ArticleDOI
Application of Artificial Intelligence for Preoperative Diagnostic and Prognostic Prediction in Epithelial Ovarian Cancer Based on Blood Biomarkers.
Eiryo Kawakami,Eiryo Kawakami,Junya Tabata,Nozomu Yanaihara,Tetsuo Ishikawa,Keita Koseki,Yasushi Iida,Misato Saito,Hiromi Komazaki,Jason Solomon Shapiro,Chihiro Goto,Yuka Akiyama,Ryosuke Saito,Motoaki Saito,Hirokuni Takano,Kyosuke Yamada,Aikou Okamoto +16 more
TL;DR: Machine learning systems can provide critical diagnostic and prognostic prediction for patients with EOC before initial intervention, and the use of predictive algorithms may facilitate personalized treatment options through pretreatment stratification of patients.
Journal Article
Homozygous deletion at chromosome 2q33 in human small-cell lung carcinoma identified by arbitrarily primed PCR genomic fingerprinting.
TL;DR: The presence of a novel tumor suppressor gene at 2q33, which is involved in the development of several human cancers, is suggested by using the arbitrarily primed polymerase chain reaction (AP-PCR), a PCR-based genomic fingerprinting.