H
Hiromi Shimada
Researcher at Kyoto Pharmaceutical University
Publications - 33
Citations - 1096
Hiromi Shimada is an academic researcher from Kyoto Pharmaceutical University. The author has contributed to research in topics: Corchorus olitorius & Scoparia. The author has an hindex of 15, co-authored 33 publications receiving 1009 citations. Previous affiliations of Hiromi Shimada include China Pharmaceutical University.
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Journal ArticleDOI
Salacinol, potent antidiabetic principle with unique thiosugar sulfonium sulfate structure from the ayurvedic traditional medicine Salacia reticulata in Sri Lanka and India
Masayuki Yoshikawa,Toshiyuki Murakami,Hiromi Shimada,Hisashi Matsuda,Johji Yamahara,Genzoh Tanabe,Osamu Muraoka +6 more
TL;DR: In this article, a most potent natural α-glucosidase inhibitor named salacinol has been isolated from an antidiabetic Ayurvedic traditional medicine, Salacia reticulata wight, through bioassay-guided separation.
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Antidiabetic Principles of Natural Medicines. II. Aldose Reductase and α-Glucosidase Inhibitors from Brazilian Natural Medicine, the Leaves of Myrcia multiflora DC. (Myrtacae) : Structures of Myrciacitrins I and II and Myrciaphenones A and B
Masayuki Yoshikawa,Hiromi Shimada,Norihisa Nishida,Yuhao Li,Iwao Toguchida,Johji Yamahara,Hisashi Matsuda +6 more
TL;DR: The methanolic extract and ethyl acetate-soluble portion from a Brazilian natural medicine, the leaves of Myrcia multiflora DC, were found to show inhibitory activities on aldose reductase and alpha-glucosidase and on the increase of serum glucose level in sucrose-loaded rats and in alloxan-induced diabetic mice.
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Medicinal Foodstuffs. V. Moroheiya. (1) : Absolute Stereostructures of Corchoionosides A, B, and C, Histamine Release Inhibitors from the Leaves of Vietnamese Corchorus olitorius L. (Tiliaceae)
Masayuki Yoshikawa,Hiromi Shimada,Masami Saka,Satoshi Yoshizumi,Johji Yamahara,Hisashi Matsuda +5 more
TL;DR: Three new ionone glucosides named corchoionosides A, B, and C were isolated from the leaves of Corchorus olitorius and were found to inhibit the histamine release from rat peritoneal exudate cells induced by antigen-antibody reaction.
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Bioactive constituents of chinese natural medicines. II. Rhodiolae radix. (1). Chemical structures and antiallergic activity of rhodiocyanosides A and B from the underground part of Rhodiola quadrifida (PALL.) FISCH. et MEY. (Crassulaceae)
Masayuki Yoshikawa,Hiromi Shimada,Hiroshi Shimoda,Nobutoshi Murakami,Johji Yamahara,Hisashi Matsuda +5 more
TL;DR: Rhodiocyanoside A, the major constituent of this natural medicine, was also found to show antiallergic activity in a passive cutaneous anaphylaxis test in rat and the chemical structures of new glycosides were determined on the basis of chemical and physicochemical evidence.
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Bioactive Constituents of Chinese Natural Medicines. I. New Sesquiterpene Ketones with Vasorelaxant Effect from Chinese Moxa, the Processed Leaves of Artemisia argyi LEVL. et VANT. : Moxartenone and Moxartenolide
TL;DR: Moxartenolide was found to inhibit the contractions induced by a high concentration of K+, by norepinephrine, and by serotonin in isolated aortic strips of rat, while moxartenone showed little activity.