H
Hiroshi Hatanaka
Publications - 65
Citations - 3695
Hiroshi Hatanaka is an academic researcher. The author has contributed to research in topics: Streptomyces tsukubaensis & Streptomyces. The author has an hindex of 14, co-authored 65 publications receiving 3578 citations.
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FR901451, a novel inhibitor of human leukocyte elastase from Flexibacter sp. I. Producing organism, fermentation, isolation, physico-chemical and biological properties.
Takashi Fujita,Hiroshi Hatanaka,Kenichi Hayashi,Nobuharu Shigematsu,Shigehiro Takase,Masanori Okamoto,Masakuni Okuhara,Kenji Shimatani,Akihiro Satoh +8 more
TL;DR: A novel human leukocyte elastase (HLE) inhibitor, FR901451 was discovered in the fermentation broth of a bacteria, which was identified as Flexibacter sp.
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Studies on new dehydropeptidase inhibitors
Seiji Hashimoto,Hidetsugu Murai,Masami Ezaki,Noriyuki Morikawa,Hiroshi Hatanaka,Masakuni Okuhara,Masanobu Kohsaka,Hiroshi Imanaka +7 more
TL;DR: WSl358Al and Bl, new potent inhibitors of renal dehydropeptidase, were isolated from the culture broth of strain No. 1358 which was identified as Streptomyces parvulus subsp.1358.
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WF14861, a new cathepsins B and L inhibitor produced by Colletotrichum sp. I. Taxonomy, production, purification and structure elucidation.
Takanao Otsuka,Yuko Muramatsu,Tomoji Fujisawa Pharmaceutical Co. Ltd. Higaki,Tomoko Nakanishi,Shigehiro Takase,Hiroshi Hatanaka,Masanori Okamoto,Motohiro Hino,Seiji Hashimoto +8 more
TL;DR: WF14861, a novel cathepsins B and L inhibitor, was obtained from the culture mycelium of a fungus strain Colletotrichum sp.
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WF14865A and B, new cathepsins B and L inhibitors produced by Aphanoascus fulvescens. I. Taxonomy, production, purification and biological properties.
Takanao Otsuka,Yuko Muramatsu,Tomoko Nakanishi,Hiroshi Hatanaka,Masanori Okamoto,Motohiro Hino,Seiji Hashimoto +6 more
TL;DR: Though their in vitro properties were typical as trans-epoxysuccinyl type inhibitors, they exerted strong bone resorption inhibitory effects in low-calcium-diet-fed mouse model at 3.2 approximately 10 mg/kg.