Hiroshi Ueno

TL;DR: Examination of the putative role of high mobility group box (HMGB) protein in the pathogenesis of acute lung injury suggests that it also plays a physiologic role in the lung and extracellular HMGB1 expression in normal airways is noteworthy and suggests this protein may play a key role in clinical and experimental ALI.

TL;DR: Observations suggest that HMGB1 could be one of the deteriorating factors in the development of VILI.

TL;DR: Results indicate that HMGB‐1 is synthesized and secreted into the DRG and spinal nerve, and contributes to the development of neuropathic pain after nerve injury, and blocking HMGB-1/RAGE signalling might thus be a promising therapeutic strategy for the management of neuropathy pain.

TL;DR: ATP induced inflammatory reactions in the lung mainly via the ATP-P2Y receptor system which were alleviated by the co-administration of a specific P2 receptor antagonist.

TL;DR: The activation of topical alveolar macrophages may be involved in the pathogenesis of pulmonary complications in the postoperative period after esophagectomy and the intensities of iNOS and inflammatory cytokines expressions in AMs were closely related to postoperative respiratory failure.