F
Fumimasa Amaya
Researcher at Kyoto Prefectural University of Medicine
Publications - 92
Citations - 5175
Fumimasa Amaya is an academic researcher from Kyoto Prefectural University of Medicine. The author has contributed to research in topics: Dorsal root ganglion & Hyperalgesia. The author has an hindex of 25, co-authored 85 publications receiving 4730 citations. Previous affiliations of Fumimasa Amaya include Harvard University.
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Journal ArticleDOI
Nociceptors are interleukin-1beta sensors
Alexander M. Binshtok,Haibin Wang,Katharina Zimmermann,Fumimasa Amaya,Daniel Vardeh,Lin Shi,Gary J. Brenner,Ru-Rong Ji,Bruce P. Bean,Clifford J. Woolf,Tarek A. Samad +10 more
TL;DR: It is shown that the proinflammatory cytokine interleukin-1 β (IL-1β), in addition to producing inflammation and inducing synthesis of several nociceptor sensitizers, also rapidly and directly activates nocICEptors to generate action potentials and induce pain hypersensitivity.
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Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
Nitin Agarwal,Pal Pacher,Irmgard Tegeder,Fumimasa Amaya,Cristina E. Constantin,Gary J. Brenner,Tiziana Rubino,Christoph W. Michalski,Giovanni Marsicano,Krisztina Monory,Ken Mackie,Claudiu Marian,Sandor Batkai,Daniela Parolaro,Michael Fischer,Peter W. Reeh,George Kunos,Michaela Kress,Beat Lutz,Clifford J. Woolf,Rohini Kuner +20 more
TL;DR: It is concluded that the contribution of CB1-type receptors expressed on the peripheral terminals of nociceptors to cannabinoid-induced analgesia is paramount, which should enable the development of peripherally acting CB1 analgesic agonists without any central side effects.
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Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity
Richard J. Mannion,Michael Costigan,Isabelle Decosterd,Fumimasa Amaya,Qing-Ping Ma,J. C. Holstege,Ru-Rong Ji,A. Acheson,Ronald M. Lindsay,G. A. Wilkinson,Clifford J. Woolf +10 more
TL;DR: BDNF, by virtue of its nerve growth factor regulation in sensory neurons including novel expression in A fibers, has a role as a central modulator of tactile stimulus-induced inflammatory pain hypersensitivity.
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Contributions of high mobility group box protein in experimental and clinical acute lung injury
Hiroshi Ueno,Tomoyuki Matsuda,Satoru Hashimoto,Fumimasa Amaya,Yoshihiro Kitamura,Masaki Tanaka,Atsuko Kobayashi,Ikuro Maruyama,Shingo Yamada,Naoki Hasegawa,Junko Soejima,Hidefumi Koh,Akitoshi Ishizaka +12 more
TL;DR: Examination of the putative role of high mobility group box (HMGB) protein in the pathogenesis of acute lung injury suggests that it also plays a physiologic role in the lung and extracellular HMGB1 expression in normal airways is noteworthy and suggests this protein may play a key role in clinical and experimental ALI.
Journal ArticleDOI
The Voltage-Gated Sodium Channel Nav1.9 Is an Effector of Peripheral Inflammatory Pain Hypersensitivity
Fumimasa Amaya,Haibin Wang,Michael Costigan,Andrew Allchorne,Jon P. Hatcher,Julie Egerton,Tania O. Stean,Valerie Morisset,David Grose,Martin J. Gunthorpe,Iain P. Chessell,Simon Tate,Paula J. Green,Clifford J. Woolf +13 more
TL;DR: Nav1.9 is, it is concluded, an effector of the hypersensitivity produced by multiple inflammatory mediators on nociceptor peripheral terminals and therefore plays a key role in mediating peripheral sensitization.