Hirotsugu Kobuchi

TL;DR: Flow cytometric analysis of freshly prepared human peripheral blood lymphocytes reveals that lipoic acid acts mainly to normalize a subpopulation of cells severely compromised in thiol status rather than to increase thiol content beyond physiological levels, suggesting it may have clinical relevance in restoration of severely glutathione deficient cells.

TL;DR: Results suggest that quercetin downregulates both PMA- and TNF-α-induced ICAM-1 expression via inhibiting both AP-1 activation and the JNK pathway.

TL;DR: Findings indicate that not only does EGb 761 directly act as an NO scavenger but also that it inhibits NO production in LPS/IFN-gamma-activated macrophages by concomitant inhibition of induction ofiNOS mRNA and the enzyme activity of iNOS.

TL;DR: The scavenging activity of Pycnogenol (the polyphenols containing extract of the bark from Pinus maritima) against reactive oxygen and nitrogen species, and its effects on NO metabolism in the murine macrophages cell line RAW 2647 are reported, which begin to provide the basis for the conceptual understanding of the biological activity of pycnogenols and possibly other polyphenolic compounds as therapeutic agents in various human disorders.

TL;DR: In this paper, the effect of various PUFAs, such as arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosapentenoic acids (DPA), on the fate of cultured human promyelocytic leukemia cells (HL-60) was investigated.