H
Hiroyoshi Hidaka
Researcher at Nagoya University
Publications - 494
Citations - 24933
Hiroyoshi Hidaka is an academic researcher from Nagoya University. The author has contributed to research in topics: Calmodulin & Protein kinase A. The author has an hindex of 73, co-authored 494 publications receiving 24619 citations. Previous affiliations of Hiroyoshi Hidaka include Case Western Reserve University & Aichi Gakuin University.
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Journal ArticleDOI
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
TL;DR: Both the holoenzyme and the catalytic subunit (or fragment), which is active without an enzyme activator, are susceptible to these compounds with a similar concentration dependency, thereby indicating that the inhibitory effect is attributed to the direct interaction of the compound with the active center of the enzyme but not with the enzymeactivator.
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Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.
Takashi Chijiwa,Atsushi Mishima,Masatoshi Hagiwara,Mamoru Sano,Kyozo Hayashi,Tsutomu Inoue,Naito Kenji,Tadashi Toshioka,Hiroyoshi Hidaka +8 more
TL;DR: In this article, a newly synthesized isoquinolinesulfonamide, H-89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinoline-sulfoneamide), was shown to have a potent and selective inhibitory action against cyclic AMP-dependent protein kinase (protein kinase A), with an inhibition constant of 0.048 +/- 0.008 microM.
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KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II
Hiroshi Tokumitsu,Takashi Chijiwa,Masatoshi Hagiwara,Akihiro Mizutani,Motomu Terasawa,Hiroyoshi Hidaka +5 more
TL;DR: Results suggest that KN-62 affects the interaction between calmodulin and Ca2+/CaM kinase II following inhibition of this kinase activity by directly binding to theCalmodulin binding site of the enzyme but does not affect the cal modulin-independent activity of already autophosphorylated (activated) enzyme.
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N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation
Hiroyoshi Hidaka,Yasuharu Sasaki,Toshio Tanaka,Toyoshi Endo,Shinichi Ohno,Yasuhisa Fujii,Tetsuji Nagata +6 more
TL;DR: This pharmacological demonstration that cytoplasmic calmodulin is involved in cell proliferation is significant; W-7 and its derivatives may be useful tools for research oncalmodulin and cell biology-related studies.
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The newly synthesized selective Ca2+calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells
Mariko Sumi,Kazutoshi Kiuchi,Tomohiko Ishikawa,Akira Ishii,Masatoshi Hagiwara,Toshiharu Nagatsu,Hiroyoshi Hidaka +6 more
TL;DR: Investigation of the inhibitory property of a newly synthesized methoxybenzenesulfonamide, KN-93, on CaMKII activity in situ and in vitro suggests that it inhibits DA formation by modulating the reaction rate of TH to reduce the Ca(2+)-mediated phosphorylation levels of the TH molecule.