Hisashi Shirakawa

TL;DR: It is suggested that a brief treatment with oxaliplatin or its metabolite oxalate is sufficient to enhance the responsiveness of TRPA1 but not that of TRPM8 and TRPV1 expressed by DRG neurons, which may contribute to the characteristic acute peripheral neuropathy induced by oxali Platin.

TL;DR: The results of the present study suggest that TRPM2 expressed in macrophages and microglia aggravates peripheral and spinal pronociceptive inflammatory responses and contributes to the pathogenesis of inflammatory and neuropathic pain.

TL;DR: Exogenous supply of d-serine as a glycine site agonist is important for neuronal injury involving NMDA receptor overactivation in the cerebral cortex, using rat brain slices maintained in a defined salt solution.

TL;DR: The role of TRP vanilloid 1 (TRPV1), a channel opened by capsaicin, heat, protons, and endovanilloids, in microglia is explored and it is indicated that mitochondrial TRPV 1 plays an important role in inducing microglial migration.

TL;DR: Thrombin dynamically upregulates TR PC3 and that TRPC3 contributes to the pathological activation of astrocytes in part through a feedforward upregulation of its own expression are suggested.