Molecular recognition of protein-ligand complexes : applications to drug design

Claisen rearrangement over the past nine decades.

In the 20 years, since the introduction of electrospray mass spectrometry (ESI-MS), the use of this technique in various fields of inorganic, organometallic, and analytical chemistry has been steadily increasing. In this study, the application of ESI-MS to the study of metal–ligand solution equilibria is reviewed (till 2004 included). In a first section, advantages and drawbacks of ESI-MS in this type of application are described. Subsequently, a list of ca. 300 studies is reported, in which ESI-MS was used to give number and stoichiometry of the species at equilibrium, or also to estimate their stability constants. All studies are classified according to the metal ions under examination. Other related applications, such as host–guest interactions and metal ion-protein binding studies, are briefly reviewed as well. © 2005 Wiley Periodicals, Inc., Mass Spec Rev 25:347–379, 2006

Electrospray mass spectrometry (ESI-MS) in the study of metal-ligand solution equilibria.

Synthesis of Polyquinane Natural Products: An Update.

Synthesis of Strychnine.

Synthese du compose du titre a partir d'5-isopropyl-2-methylcyclopent-1-ene carbaldehyde via la transposition Claisen d'un derive de cyclopenta pyrane en derive de cyclopenta cyclooctene

Synthetic studies on basmane diterpenes. Enantiospecific total synthesis of (+)-7,8-epoxy-2-basmen-6-one by Claisen ring expansion

The first total synthesis of the title compound has been accomplished. Besides the immediate establishment of the trans cyclopropane-lactone relationship by an appropriate Diels-Alder reaction, other notable transformations include a regioselective chain-lengthening, oxadi-π-methane rearrangement, lactone ring construction by an intramolecular Michael reaction-oxidation sequence, and use of monomeric formaldehyde to introduce the final carbon atom. The chemistry outlined defines a strategy that is highly stereocontrolled and completely tolerant of a sterically congested cyclopropane ring that is carried through to the target from the very first step

Stereocontrolled Access to the Most Highly Condensed Pentalenolactone Antibiotic. from Cycloheptatriene to Pentalenolactone P Methyl Ester

Synthese du compose du titre a partir d'isopropyl 3 methyl-1 methylene-2 cyclopentaneacetaldehyde via une transposition Claisen d'isopropyl-7 hexahydro methyl-4a methylene-2 propenyl-7a cyclopenta [b] pyranne en isopropyl-1 dimethyl-3a,8 hexahydro cyclopentacyclooctenone-6

Claisen-based strategy for the de novo construction of basmane diterpenes. Enantiospecific synthesis of (+)-7,8-epoxy-2-basmen-6-one

Stereocontrolled total synthesis of (.+-.)-pentalenolactone P methyl ester

The structural features most conducive to complexation of the alkali metal ions Li+, Na+, and K+ in a series of constrained inositol orthoformate derivatives have been probed in solution, in the so...

Constraining of small-ring cyclic ether triads by stereodefined spiroannulation to an inositol orthoformate platform. Solution- and gas-phase alkali metal binding affinities for three- to five-membered ring structural combinations.

Ho Jung Kang

Papers

Synthetic studies on basmane diterpenes. Enantiospecific total synthesis of (+)-7,8-epoxy-2-basmen-6-one by Claisen ring expansion

Stereocontrolled Access to the Most Highly Condensed Pentalenolactone Antibiotic. from Cycloheptatriene to Pentalenolactone P Methyl Ester

Claisen-based strategy for the de novo construction of basmane diterpenes. Enantiospecific synthesis of (+)-7,8-epoxy-2-basmen-6-one

Stereocontrolled total synthesis of (.+-.)-pentalenolactone P methyl ester

Constraining of small-ring cyclic ether triads by stereodefined spiroannulation to an inositol orthoformate platform. Solution- and gas-phase alkali metal binding affinities for three- to five-membered ring structural combinations.