H
Holger Sigusch
Researcher at University of Oulu
Publications - 1
Citations - 93
Holger Sigusch is an academic researcher from University of Oulu. The author has contributed to research in topics: Biological activity & Enzyme inhibitor. The author has an hindex of 1, co-authored 1 publications receiving 91 citations.
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Differential inhibition of coumarin 7-hydroxylase activity in mouse and human liver microsomes
Jukka Mäenpää,Holger Sigusch,Hannu Raunio,Tuula Syngelmä,Pia Vuorela,Heikki Vuorela,Olavi Pelkonen +6 more
TL;DR: The results suggest that the coumarin-type compounds in particular interact with the active sites of Cyp2a-5 and CYP2A6, and the active Sites are structurally different, since a number of compounds inhibited mouse, but not human COH activity.