Holly Anger

TL;DR: The study results suggest an excellent efficacy but also the necessity of caution in the prescription of linezolid, and the proportion of adverse events was significantly higher when the lineZolid daily dosage exceeded 600 mg.

TL;DR: The majority of MDR TB patients on linezolid had favourable treatment outcomes, although treatment was complicated by adverse events that required extensive clinical management.

TL;DR: It is advocated that a woman should be given the option to continue treatment of MDR-TB rather than terminating pregnancy or discontinuing M DR-TB treatment, and the birth outcomes of the cohort are similar to those among the general Peru population.

TL;DR: In this paper, the authors search the NYC tuberculosis registry to identify contacts developing active tuberculosis within 4 years of follow-up and find that active tuberculosis was diagnosed in 46 contacts with LTBI, including 22 of 6001 (0.4%) who initiated chemoprophylaxis and 24 of 1596 (1.5%) who did not initiate treatment.

TL;DR: Concordant genotype results and a high proportion of contacts developing active TB disease within 2 years of exposure indicate that those with prior positive TST results likely developed activeTB disease from recent rather than remote infection.