J
Jan-William C. Alffenaar
Researcher at University of Groningen
Publications - 14
Citations - 413
Jan-William C. Alffenaar is an academic researcher from University of Groningen. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 2, co-authored 2 publications receiving 353 citations.
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Journal ArticleDOI
Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis
Giovanni Sotgiu,Rosella Centis,Lia D'Ambrosio,Jan-William C. Alffenaar,Holly Anger,Jose A. Caminero,Paolo Castiglia,Saverio De Lorenzo,Giovanni Ferrara,Giovanni Ferrara,Won-Jung Koh,Giesela F. Schecter,Tae Sun Shim,Rupak Singla,Alena Skrahina,Antonio Spanevello,Zarir F Udwadia,Miguel Villar,Elisabetta Zampogna,Jean-Pierre Zellweger,Alimuddin Zumla,Giovanni Battista Migliori +21 more
TL;DR: The study results suggest an excellent efficacy but also the necessity of caution in the prescription of linezolid, and the proportion of adverse events was significantly higher when the lineZolid daily dosage exceeded 600 mg.
Journal ArticleDOI
Therapeutic drug monitoring: how to improve drug dosage and patient safety in tuberculosis treatment
Giovanni Sotgiu,Jan-William C. Alffenaar,Rosella Centis,Lia D'Ambrosio,Antonio Spanevello,Andrea Piana,Giovanni Battista Migliori +6 more
TL;DR: The role and contribution of therapeutic drug monitoring (TDM) is discussed in detail, with the 'dried blood spot' technique providing the rationale for discussions regarding a possible future network of selected, quality-controlled reference laboratories for the processing of dried blood spots of difficult-to-treat patients from reference TB clinics around the world.
Journal ArticleDOI
Clinical standards for the dosing and management of TB drugs
Jan-William C. Alffenaar,Sophie L. Stocker,Lina Davies Forsman,A. Garcia-Prats,Scott K. Heysell,Rob E. Aarnoutse,Onno W. Akkerman,Alena Aleksa,R. van Altena,W. A. de Oñata,P. K. Bhavani,Natasha van't Boveneind-Vrubleuskaya,A. Carvalho,Rosella Centis,Jeremiah Chakaya,Daniela Maria Cirillo,J. Cho,L. D Ambrosio,Margareth Pretti Dalcolmo,Paolo Denti,Keertan Dheda,Gregory J. Fox,A. Hesseling,H. Y. Kim,Claudio U. Köser,Ben J. Marais,Ioana Margineanu,Anne-Grete Märtson,Marcela Muñoz Torrico,Heda Melinda Nataprawira,Chee Wui Ong,R Otto-Knapp,Charles A. Peloquin,D. Rossato Silva,Rovina Ruslami,Prayudi Santoso,Radojka M. Savic,R. Singla,Elin M. Svensson,Alena Skrahina,Dick van Soolingen,Sharmistha Aich Srivastava,Marina Tadolini,S. Tiberi,Tania A Thomas,Z Udwadia,Dinh Hoa Vu,W. Zhang,Stellah G. Mpagama,Thomas B. Schön,G. B. Migliori +50 more
TL;DR: This is the first consensus-based Clinical Standards for the dosing and management of TB drugs to guide clinicians and programme managers in planning and implementation of locally appropriate measures for optimal person-centred treatment to improve patient care.
Journal ArticleDOI
An Inca trail to the Holy Grail: digital medication adherence support for TB care.
Journal ArticleDOI
Clinical standards for drug-susceptible pulmonary TB
Onno W. Akkerman,Raquel Duarte,S. Tiberi,H. Simon Schaaf,C. Lange,Jan-William C. Alffenaar,J. Denholm,A. Carvalho,Mathieu S. Bolhuis,Sergey Borisov,Judith Bruchfeld,A. Cabibbe,J.A. Caminero,Isabel Carvalho,Jeremiah Chakaya,Rosella Centis,Margareth Dalcomo,L. D Ambrosio,ML Dedicoat,Keertan Dheda,Kelly E. Dooley,J Furin,José Mª García-García,N. A. H. Van Hest,Bouke C. de Jong,Xhevat Kurhasani,Anne-Grete Märtson,Stellah G. Mpagama,Marcela Muñoz Torrico,Elizabete Nunes,Chee Wui Ong,Domingo Palmero,Rovina Ruslami,Antonia Morita Iswari Saktiawati,C. Semuto,Daniela Rosa da Silva,R. Singla,Ivan Solovic,Shobha Srivastava,Jurriaan E. M. de Steenwinkel,Al Story,Marieke G G Sturkenboom,Marina Tadolini,Z Udwadia,Anna Verhage,J. Zellweger,G. B. Migliori +46 more
TL;DR: These consensus-based clinical standards will help to improve patient care by guiding clinicians and programme managers in planning and implementation of locally appropriate measures for optimal person-centred treatment for PTB.