H
Holly Symonds
Researcher at University of North Carolina at Chapel Hill
Publications - 4
Citations - 1058
Holly Symonds is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Antigen & Apoptosis. The author has an hindex of 3, co-authored 4 publications receiving 1050 citations.
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Journal ArticleDOI
p53-Dependent apoptosis suppresses tumor growth and progression in vivo
Holly Symonds,Leonard Krall,Lee Remington,Mayte Saenz-Robles,Scott W. Lowe,Tyler Jacks,Tyler Jacks,Terry Van Dyke +7 more
TL;DR: In vivo evidence is provided that p53-dependent apoptosis, occurring in response to oncogenic events, is a critical regulator of tumorigenesis.
Journal ArticleDOI
Regulation of apoptosis in transgenic mice by simian virus 40 T antigen-mediated inactivation of p53
TL;DR: It is demonstrated that the simian virus 40 large tumor (T) antigen produces a loss-of-p53-function phenotype when introduced into the thymocytes of transgenic mice and suggested a mechanism by which T antigen predisposes thymocyte to tumorigenesis in T antigen-transgenic mice.