Showing papers by "Hong-Bo Li published in 2014"
TL;DR: Overall, SBRC-GP had potential to predict Pb RBA in dust samples, however, it is suggested that more research is needed to develop a valid in vitro method for predicting PbRBA in house dust.
Abstract: House dust samples containing 25−738 mg of Pb kg −1 from 15 cities in China were assessed for in vitro Pb bioaccessibility and in vivo Pb relative bioavailability. On the basis of stable Pb isotope ratios, the Pb in dust samples mainly originated from coal combustion. Lead bioaccessibility was determined using gastric (GP) and intestinal phase (IP) of solubility bioaccessibility research consortium (SBRC), in vitro gastrointestinal (IVG), Deutsches Institut fu Normunge.V. (DIN), and physiologically based extraction test methods (PBET), while Pb relative bioavailability (RBA) was determined using a mouse blood model. Lead bioaccessibility in 24 house dust samples varied significantly (23−99%) depending on the methods. Values from the IP were considerably lower than those from the GP because of the co-precipitation of Pb with iron and re-adsorption onto the dust matrix. The SBRC assay with lower GP pH produced higher Pb bioaccessibility because of enhanced Pb dissolution. When compared to mouse blood data using 12 dust samples (29−60%), SBRC−GP and DIN−GP data were correlated with Pb RBA with r 2 values of 0.68 and 0.85 and intercepts 3.15 and 17.4, respectively. Overall, SBRC−GP had potential to predict Pb RBA in dust samples. However, our data suggested that more research is needed to develop a valid in vitro method for predicting Pb RBA in house dust.
97 citations
TL;DR: Results showed that, one year after the lead control, lead concentrations sharply decreased in both environmental and biological samples with a decrease of 0.43 μg/m3 in ambient air samples and 6.24 μg/dL in childhood blood lead levels (BLL).
Abstract: Children's blood lead levels and prevalence of lead poisoning in China are significantly higher than in developed countries, though a substantial decrease has been observed. Since 2011, strict lead control policies in lead-related industries have been implemented in China, but the success of these policies is unknown. In this study, we collected environmental samples, questionnaire data, and blood samples from 106 children from 1 to 14 years old, before and after implementation of lead-usage control policy in wire rope factories by local government in Zhuhang, Nantong in 2012. Results showed that, one year after the lead control, lead concentrations sharply decreased in both environmental and biological samples with a decrease of 0.43 μg/m3 (-84.3%) in ambient air samples, 0.22 mg/kg (-36.1%) in vegetable samples, 441.1 mg/kg (-43.7%) in dust samples, and 6.24 μg/dL (-51.5%) in childhood blood lead levels (BLL). This study demonstrates the success of lead control policies in promoting the prevention and control of childhood lead poisoning in Nantong, China.
62 citations
TL;DR: Although AsIII was oxidized to AsV during the experiment, As species impacted As accumulation by PV, with 17.5% more As in AsIII- soil than AsV-soil (36 vs. 31 mg plant(-1).
53 citations
TL;DR: The data suggested that both SBRC and DIN had potential to assess As bioavailability in household dust samples; however, additional research is needed.
Abstract: Incidental ingestion of household dust is an important arsenic (As) exposure pathway for children. However, compared to soils, assessment of As relative bioavailability (RBA) in household dust is limited. In this study, As-RBA in 12 household dust samples (7−38 mg kg −1 ) was measured using an in vivo mouse model and compared to As bioaccessibility determined using 4 assays (Solubility Bioaccessibility Research Consortium method (SBRC), in vitro gastrointestinal method (IVG), Deutsches Institut fu Normunge.V. method (DIN), and physiologically based extraction test (PBET)). Arsenic RBA ranged from 21.8 ± 1.6 to 85.6 ± 7.2% with samples containing low Fe and high total organic carbon content having higher As-RBA. Strong in vivo−in vitro correlations (IVIVC) were found between As-RBA and As bioaccessibility for SBRC and DIN (r 2 = 0.63−0.85), but weaker ones were obtained for IVG and PBET (r 2 = 0.29−0.55). The developed IVIVC for SBRC and DIN were used to calculate As-RBA based on As bioaccessibility for an additional 12 household dust samples. Although As bioaccessibility differed significantly (up to 7.7-fold) based on in vitro methods, predicted As-RBA was less variable (up to 3.0-fold) when calculated using As bioaccessibility data and the corresponding IVIVC. Our data suggested that both SBRC and DIN had potential to assess As bioavailability in household dust samples; however, additional research is needed.
39 citations