H
Hong-Chang Guan
Researcher at University of Toronto
Publications - 26
Citations - 6725
Hong-Chang Guan is an academic researcher from University of Toronto. The author has contributed to research in topics: Dopamine receptor D2 & Dopamine receptor. The author has an hindex of 20, co-authored 26 publications receiving 6613 citations.
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Journal ArticleDOI
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine.
Hubert H.M. Van Tol,James R. Bunzow,Hong-Chang Guan,Roger K. Sunahara,Philip Seeman,Hyman B. Niznik,Olivier Civelli +6 more
TL;DR: The cloning of a gene that encodes a dopamine receptor gene that has high homology to the human dopamine D2 and D3 receptor genes is reported, which suggests the existence of other types of dopamine receptors which are more sensitive to clozapine.
Journal ArticleDOI
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1
Roger K. Sunahara,Hong-Chang Guan,Brian F. O'Dowd,Philip Seeman,Lisanne G. Laurier,Gordon Y.K. Ng,Susan R. George,J. Torchia,H. H. M. Van Tol,Hyman B. Niznik +9 more
TL;DR: The cloning of a gene encoding a 477-amino-acid protein with strong homology to the cloned Dt receptor is reported here the existence of a dopamine D1-like receptor with these characteristics had not been predicted and may represent an alternative pathway for dopamine-mediated events and regulation of D2 receptor activity.
Journal ArticleDOI
Multiple dopamine D4 receptor variants in the human population
Van Tol Hh,Wu Cm,Hong-Chang Guan,K. Ohara,Bunzow,Olivier Civelli,James L. Kennedy,Philip Seeman,Hyman B. Niznik,Jovanovic +9 more
TL;DR: This is the first report of a receptor in the catecholamine receptor family that displays polymorphic variation in the human population and such variation among humans may underlie individual differences in susceptibility to neuropsychiatric disease and in responsiveness to antipsychotic medication.
Journal ArticleDOI
Dopamine D4 receptors elevated in schizophrenia
TL;DR: It is concluded that the combined density of D2 and D3 receptors (labelled by [3H]raclopride) is increased by only 10% in schizophrenia brain, as found by Farde et al.15, but that it is the density of dopamine D4 receptors which is sixfold elevated in schizophrenia.
Journal ArticleDOI
Human brain dopamine receptors in children and aging adults.
Philip Seeman,Natalie H. Bzowej,Hong-Chang Guan,Catherine Bergeron,Lawrence E. Becker,Gavin P. Reynolds,Edward D. Bird,Peter Riederer,Kurt A. Jellinger,Shuzo Watanabe,Wallace W. Tourtellotte +10 more
TL;DR: The observed decline in the human D1/D2 ratio with age suggests that the perioral control mechanisms for humans and rats may be different.