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Brian F. O'Dowd
Researcher at Centre for Addiction and Mental Health
Publications - 149
Citations - 18243
Brian F. O'Dowd is an academic researcher from Centre for Addiction and Mental Health. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 74, co-authored 149 publications receiving 17540 citations. Previous affiliations of Brian F. O'Dowd include University of Toronto.
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Journal ArticleDOI
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1
Roger K. Sunahara,Hong-Chang Guan,Brian F. O'Dowd,Philip Seeman,Lisanne G. Laurier,Gordon Y.K. Ng,Susan R. George,J. Torchia,H. H. M. Van Tol,Hyman B. Niznik +9 more
TL;DR: The cloning of a gene encoding a 477-amino-acid protein with strong homology to the cloned Dt receptor is reported here the existence of a dopamine D1-like receptor with these characteristics had not been predicted and may represent an alternative pathway for dopamine-mediated events and regulation of D2 receptor activity.
Journal ArticleDOI
A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11
Brian F. O'Dowd,Michael Heiber,Audrey Chan,Henry H.Q. Heng,Lap-Chee Tsui,James L. Kennedy,Xiao-Mei Shi,Arturas Petronis,Susan R. George,Tuan V. Nguyen +9 more
TL;DR: PCR analysis of somatic cell lines found APJ-related sequences to be only present on chromosome 11, and high-resolution mapping by fluorescence in situ hybridization (FISH) sublocalized APJ on band q12.
Journal ArticleDOI
Characterization of the human cysteinyl leukotriene 2 receptor.
Christopher E. Heise,Brian F. O'Dowd,David J. Figueroa,Nicole Sawyer,Tuan V. Nguyen,Dong Soon Im,Rino Stocco,Julie N. Bellefeuille,Mark Abramovitz,Regina Cheng,David L. Williams,Zhizhen Zeng,Qingyun Liu,Lei Ma,Michelle K. Clements,Nathalie Coulombe,Yuan Liu,Christopher P. Austin,Susan R. George,Gary P. O'Neill,Kathleen M. Metters,Kevin R. Lynch,Jilly F. Evans +22 more
TL;DR: The cloning and characterization of the second cysteinyl leukotriene receptor, CysLT2, a 346-amino acid protein with 38% amino acid identity to the Cys LT1 receptor is described and demonstrated high affinity binding and a rank order of potency for competition of LTC4 = LTD4 ≫ LTE4.
Journal ArticleDOI
Characterization of Apelin, the Ligand for the APJ Receptor
Dennis Lee,Regina Cheng,Tuan V. Nguyen,Theresa Fan,Anula Kariyawasam,Yang Liu,Daniel H. Osmond,Susan R. George,Susan R. George,Brian F. O'Dowd,Brian F. O'Dowd +10 more
TL;DR: Both sequence and mRNA expression distribution analyses revealed similarities between apelin and angiotensin II, suggesting they that share related physiological roles.
Journal ArticleDOI
Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties.
Susan R. George,Susan R. George,Theresa Fan,Zhidong Xie,Roderick Tse,Vincent C. Tam,George Varghese,Brian F. O'Dowd +7 more
TL;DR: Evidence is provided for the direct interaction of mu- and delta-opioid receptors to form oligomers, with the generation of novel pharmacology and G protein coupling properties.