H
Hong Chen
Researcher at Fujian Medical University
Publications - 3
Citations - 126
Hong Chen is an academic researcher from Fujian Medical University. The author has contributed to research in topics: Pyroptosis & Apoptosis. The author has an hindex of 2, co-authored 3 publications receiving 38 citations.
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RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD.
TL;DR: It is shown that the upregulated expression and interactions between RIPK3 and MLKL induced necroptosis of renal proximal tubular cells and contributed to NLRP3 inflammasome activation under the conditions of IRI, which indicates that necroinflammation driven byRIPK3-MLKL-dependent ne croptosis plays a crucial role in the progression of I RI to CKD.
Journal ArticleDOI
GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy.
Yinshuang Li,Ying Yuan,Zhong-Xing Huang,Hui Chen,Ruilong Lan,Zeng Wang,Kunmei Lai,Hong Chen,Zhimin Chen,Zhenhuan Zou,Hua-Bin Ma,Hui-Yao Lan,Tak W. Mak,Tak W. Mak,Yanfang Xu +14 more
TL;DR: In this paper, the authors showed that TNFα/Casp3/GSDME-mediated pyroptosis is responsible for the initiation of ureteral obstruction-induced renal tubule injury, which subsequentially contributes to the late stage progression of hydronephrosis, inflammation and fibrosis.
Journal ArticleDOI
Prioritization of Diagnostic and Prognostic Biomarkers for Lupus Nephritis Based on Integrated Bioinformatics Analyses.
TL;DR: In this paper, the WGCNA and R limma packages were used to identify LN hub genes and differentially-expressed genes (DEGs) from the GEO database.