Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: synthetic approaches and multifarious applications.

Fluoride ion catalyzed multicomponent reactions for efficient synthesis of 4H-chromene and N-arylquinoline derivatives in aqueous media

Quinoline is one of the most widely investigated scaffolds by synthetic chemists because of its medicinal importance. A wide range of metal-catalyzed, metal-free, multi-step or domino one-pot protocols are reported in the literature for construction of this scaffold. Several reviews have appeared on synthetic aspects of this scaffold, however there is no focused review on metal-free domino one-pot protocols. Domino one-pot protocols offer an opportunity to access highly functionalized final products from simple starting materials. Because of this unique feature of domino protocols, in recent years their utility for generation of molecular libraries has been widely appreciated. In this review, all contributions till March 2015 are surveyed with particular emphasis on metal-free domino reactions for quinoline ring construction and are discussed herein along with mechanistic aspects.

Metal-free domino one-pot protocols for quinoline synthesis

Green recipes to quinoline: A review

This work was funded by the UK Biotechnology and Biological Sciences Research Council (BBSRC) Structural Proteomics of Rational Targets (SPoRT) initiative, (Grant BBS/B/14434). Funding to pay the Open Access publication charges for this article was provided by BBSRC.

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TarO: a target optimisation system for structural biology

Structurally diversified products from the reactions of 2-aminobenzamides with 1,3-cyclohexanediones catalyzed by iodine

Iodine‐Catalyzed Synthesis of Cyclopenta[c]quinoline Derivatives via Imino Diels–Alder Reaction

A series of 1,4-diarylquinoline derivatives were synthesized by the reaction of arylmethylidene-malononitriles or 2-cyano-3-aryl-1-acrylate and 3-arylamino-5,5-dimethylcyclohex-2-enone in aqueous media at 100 °C catalyzed by TEBAC. Meanwhile, the water medium was chosen as green solvent.

A Clean Synthesis of 1,4-Diarylquinoline Derivatives Catalyzed by TEBAC in Aqueous Media

A series of cyclopenta[b]chromen-1(9H)-one derivatives is prepared in high yields by a one-pot reaction of substituted salicylaldehydes and cyclopentane-1,3-dione in ionic liquids of [BMIm]Br, the procedure is very mild and environmentally benign.

Hong Jiang

Papers

Structurally diversified products from the reactions of 2-aminobenzamides with 1,3-cyclohexanediones catalyzed by iodine

Iodine‐Catalyzed Synthesis of Cyclopenta[c]quinoline Derivatives via Imino Diels–Alder Reaction

A Clean Synthesis of 1,4-Diarylquinoline Derivatives Catalyzed by TEBAC in Aqueous Media

A Green Method for the Synthesis of Cyclopenta[b]chromen‐1(9H)‐one Derivatives in Ionic Liquids

2-Amino-4-(2-chlorophenyl)-7,7-dimethyl-1-(4-methylphenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile