H
Hong Rong
Researcher at Bayer
Publications - 3
Citations - 3806
Hong Rong is an academic researcher from Bayer. The author has contributed to research in topics: Receptor tyrosine kinase & Mitogen-activated protein kinase. The author has an hindex of 2, co-authored 2 publications receiving 3596 citations.
Papers
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Journal ArticleDOI
BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis
Scott Wilhelm,Christopher A. Carter,LiYa Tang,Dean Wilkie,Angela McNabola,Hong Rong,Charles Chen,Xiaomei Zhang,Patrick Vincent,Mark McHugh,Yichen Cao,Jaleel Shujath,Susan Gawlak,Deepa Eveleigh,Bruce Rowley,Li Liu,Lila Adnane,Mark Lynch,Daniel Auclair,Ian W. Taylor,Rich Gedrich,Andrei Voznesensky,Bernd Riedl,Leonard Post,Gideon Bollag,Pamela A. Trail +25 more
TL;DR: Data demonstrate that BAY 43-9006 is a novel dual action RAF kinase and VEGFR inhibitor that targets tumor cell proliferation and tumor angiogenesis.
Journal ArticleDOI
Omega-carboxypyridyl substituted ureas as Raf kinase inhibitors: SAR of the amide substituent.
Uday Khire,Donald Bankston,James Barbosa,David R. Brittelli,Yolanda V Caringal,Robert O. Carlson,Jacques Dumas,Todd Gane,Sarah Heald,Barbara Hibner,Jeffrey Johnson,Michael E Katz,Nancy Kennure,Jill Kingery-Wood,Wendy Lee,Xiao-Gao Liu,Timothy B. Lowinger,Ian McAlexander,Mary-Katherine Monahan,Reina Natero,Joel Renick,Bernd Riedl,Hong Rong,Robert Sibley,Roger A. Smith,Donald John Wolanin +25 more
TL;DR: Modifications in the amide portion led to an improvement in aqueous solubility, an important characteristic for an oral drug, and it is hypothesize that this portion of the molecule is directed towards the solvent in Raf-1.
Journal ArticleDOI
Fluorescence labeling of extracellular vesicles for diverse bio-applications in vitro and in vivo.
TL;DR: In this paper , the authors survey the latest advances regarding extracellular vesicle fluorescence labeling strategies and their application in biomedical application and in vivo biology investigation, highlighting the progresses in individual EV imaging.