H
Hongbing Zhang
Researcher at Peking Union Medical College
Publications - 99
Citations - 6159
Hongbing Zhang is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & TSC1. The author has an hindex of 33, co-authored 90 publications receiving 5302 citations. Previous affiliations of Hongbing Zhang include Dalian Medical University & Peking Union Medical College Hospital.
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Journal ArticleDOI
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
David J. Kwiatkowski,Hongbing Zhang,Jennifer L. Bandura,Kristina M. Heiberger,Michael Glogauer,Nisreen El-Hashemite,Hiroaki Onda +6 more
TL;DR: A murine model of Tsc1 disease by gene targeting shows constitutive activation of the mTOR-S6K pathway due to loss of the TSC1 protein, hamartin, andHyperphosphorylation of S6 is also seen in kidney tumors in the heterozygote mice, suggesting that inhibition of this pathway may have benefit in control of TSC hamartomas.
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Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
Qian Sun,Xinxin Chen,Jianhui Ma,Haiyong Peng,Fang Wang,Xiaojun Zha,Yanan Wang,Yanling Jing,Hongwang Yang,Rongrong Chen,Long Chang,Yu Zhang,June Goto,Hiroaki Onda,Tong Chen,Ming-Rong Wang,Youyong Lu,Han You,David J. Kwiatkowski,Hongbing Zhang +19 more
TL;DR: Components of the mTOR/HIF1α/Myc–hnRNPs/PKM2 glycolysis signaling network could be targeted for the treatment of cancer caused by an aberrant RTK/PI3K/AKT/mTOR signaling pathway.
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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
Hongbing Zhang,Gregor Cicchetti,Hiroaki Onda,Henry B. Koon,Kirsten Asrican,Natalia Bajraszewski,Francisca Vazquez,Christopher L. Carpenter,David J. Kwiatkowski +8 more
TL;DR: In this paper, TSC1/Tsc2 does not bind directly to mTOR, nor does it directly influence mTOR kinase activity or cellular phosphatase activity.
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PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR
Hongbing Zhang,Natalia Bajraszewski,Erxi Wu,Hong-Wei Wang,Annie P. Moseman,Sandra L. Dabora,James D. Griffin,David J. Kwiatkowski +7 more
TL;DR: PDGFR is a major target of negative feedback regulation in cells with activated mTOR, which limits the growth potential of TSC tumors.
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Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation.
Jennifer A. Chan,Hongbing Zhang,Penelope S. Roberts,Sergiusz Jozwiak,Grajkowska Wieslawa,Joanna Lewin-Kowalik,Katarzyna Kotulska,David J. Kwiatkowski +7 more
TL;DR: It is concluded that TSC SEGAs likely arise through a two-hit mechanism of biallelic inactivation of TSC1 or TSC2, leading to activation of the mTOR kinase.