Y
Yu Zhang
Researcher at Peking University
Publications - 526
Citations - 18167
Yu Zhang is an academic researcher from Peking University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 56, co-authored 386 publications receiving 14501 citations. Previous affiliations of Yu Zhang include Harvard University & Novartis.
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Journal ArticleDOI
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo
TL;DR: The data provide evidence that HDAC‐6 might act as a dual deacetylase for tubulin and histones, and suggest the possibility that acetylated non‐histone proteins might represent novel targets for pharmacological therapy by HDAC inhibitors.
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LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer
Yan Wang,Hua Zhang,Yupeng Chen,Yimin Sun,Fen Yang,Wenhua Yu,Jing Liang,Luyang Sun,Xiaohan Yang,Lei Shi,Ruifang Li,Yanyan Li,Yu Zhang,Qian Li,Xia Yi,Yongfeng Shang +15 more
TL;DR: It is found that LSD1 is downregulated in breast carcinomas and that its level of expression is negatively correlated with that of TGFbeta1, which provides a molecular basis for the interplay of histone demethylation and deacetylation in chromatin remodeling.
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Spatial Organization of the Mouse Genome and Its Role in Recurrent Chromosomal Translocations
Yu Zhang,Rachel Patton McCord,Yu-Jui Ho,Bryan R. Lajoie,Dominic G. Hildebrand,Alince C. Simon,Michael B. Becker,Frederick W. Alt,Job Dekker +8 more
TL;DR: A high-resolution Hi-C spatial organization map of the G1-arrested mouse pro-B cell genome is generated and high-throughput genome-wide translocation sequencing is used to map translocations from target DNA double-strand breaks (DSBs) within it.
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Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally
Yu Zhang,So Hee Kwon,Teppei Yamaguchi,Fabien Cubizolles,Sophie Rousseaux,Michaela Kneissel,Chun Cao,Na Li,Hwei Ling Cheng,Katrin F. Chua,David B. Lombard,Adam Mizeracki,Gabriele Matthias,Frederick W. Alt,Saadi Khochbin,Patrick Matthias +15 more
TL;DR: It is demonstrated that mice survive well without HDAC6 and that tubulin hyperacetylation is not detrimental to normal mammalian development, and that this deacetylase plays a minor role in bone biology.
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Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
Qian Sun,Xinxin Chen,Jianhui Ma,Haiyong Peng,Fang Wang,Xiaojun Zha,Yanan Wang,Yanling Jing,Hongwang Yang,Rongrong Chen,Long Chang,Yu Zhang,June Goto,Hiroaki Onda,Tong Chen,Ming-Rong Wang,Youyong Lu,Han You,David J. Kwiatkowski,Hongbing Zhang +19 more
TL;DR: Components of the mTOR/HIF1α/Myc–hnRNPs/PKM2 glycolysis signaling network could be targeted for the treatment of cancer caused by an aberrant RTK/PI3K/AKT/mTOR signaling pathway.