Hongying Yu

TL;DR: In this paper, the authors describe the temporal trends in respiratory outcomes over 12 months in patients hospitalised for severe COVID-19 and investigate the associated risk factors, including a history of hypertension, diabetes, cardiovascular disease, cancer, and chronic lung disease, including asthma or chronic obstructive pulmonary disease.

TL;DR: The data reveal that type II NKT cells activated by glycolipids, such as sulfatide, may serve as a novel approach to treat allergic diseases and other disorders characterized by inappropriate type I NKT cell activation.

TL;DR: The results suggest that iNKT cells may serve as an adjuvant to enhance Th2 inflammatory response in an OVA-induced murine model of asthma.

TL;DR: L lung interstitial macrophages undergo a phenotypic switch from a regulatory macrophage phenotype under normal conditions to an alternative activation state in OVA-induced asthmatic mice, suggesting a role for regulation in the pathophysiology of asthma.

TL;DR: The findings indicate that intraperitoneal administration of α-GalCer before the development of asthma symptoms induces the generation of lung Treg cells via iNKT cells and may provide a potential therapeutic strategy to prevent allergic asthma.