H
Hoonkyo Suh
Researcher at Cleveland Clinic
Publications - 37
Citations - 4454
Hoonkyo Suh is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Neurogenesis & Neural stem cell. The author has an hindex of 19, co-authored 36 publications receiving 4049 citations. Previous affiliations of Hoonkyo Suh include Salk Institute for Biological Studies & Cleveland Clinic Lerner Research Institute.
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Journal ArticleDOI
In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus.
TL;DR: An asymmetric contribution of Sox2+ NSCs may play an important role in maintaining the constant size of the NSC pool and producing newly born neurons during adult neurogenesis.
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Dosage requirement of Pitx2 for development of multiple organs.
TL;DR: This allelic series establishes that Pitx2 is required for the development of mulitple organs in a dosage-sensitive manner as well as left-right asymmetry of the lungs but not other organs.
Journal ArticleDOI
BRCA1 tumour suppression occurs via heterochromatin-mediated silencing.
Quan Zhu,Gerald M. Pao,Alexis M. Huynh,Alexis M. Huynh,Hoonkyo Suh,Hoonkyo Suh,Nina Tonnu,Petra M. Nederlof,Fred H. Gage,Inder M. Verma +9 more
TL;DR: It is proposed that the role of BRCA1 in maintaining global heterochromatin integrity accounts for many of its tumour suppressor functions.
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Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus.
Helena Mira,Helena Mira,Zoraida Andreu,Zoraida Andreu,Hoonkyo Suh,Hoonkyo Suh,D. Chichung Lie,Sebastian Jessberger,Sebastian Jessberger,Antonella Consiglio,Juana San Emeterio,Rafael Hortigüela,María Ángeles Marqués-Torrejón,Kinichi Nakashima,Kinichi Nakashima,Dilek Colak,Magdalena Götz,Isabel Fariñas,Fred H. Gage +18 more
TL;DR: It is shown that bone morphogenetic protein (BMP) signaling is active in hippocampal NSCs, downstream of BMPR-IA, and is required to balance NSC quiescence/proliferation and to prevent loss of the stem cell activity that supports continuous neurogenesis in the mature hippocampus.
Journal ArticleDOI
Signaling in adult neurogenesis.
TL;DR: Understanding signaling in adult Neurogenesis is not only important to understand the physiological roles of neurogenesis, but also to provide knowledge that is essential for developing therapeutic applications using NSCs to intervene in the progression of brain diseases.