H
Horacio Ramirez
Researcher at University of Miami
Publications - 11
Citations - 1407
Horacio Ramirez is an academic researcher from University of Miami. The author has contributed to research in topics: Wound healing & Diabetes mellitus. The author has an hindex of 9, co-authored 10 publications receiving 996 citations. Previous affiliations of Horacio Ramirez include Tufts University.
Papers
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Journal ArticleDOI
Epithelialization in Wound Healing: A Comprehensive Review
Irena Pastar,Olivera Stojadinovic,Natalie C. Yin,Horacio Ramirez,Aron G. Nusbaum,Andrew P. Sawaya,Shailee Patel,Laiqua Khalid,R. Isseroff,Marjana Tomic-Canic +9 more
TL;DR: The pivotal role of keratinocytes in epithelialization is focused on, including cellular processes and mechanisms of their regulation during re-epithelialization, and their cross talk with other cell types participating in wound healing.
Journal ArticleDOI
The Role of TGFβ Signaling in Wound Epithelialization
TL;DR: A better understanding of TGFβ signaling may provide new insights not only in the normal epithelialization process, but also in tissue regeneration, which may lead to development of novel therapeutic advances for chronic wounds.
Journal ArticleDOI
A bioengineered living cell construct activates an acute wound healing response in venous leg ulcers.
Rivka C. Stone,Olivera Stojadinovic,Ashley M. Rosa,Horacio Ramirez,Evangelos V. Badiavas,Miroslav Blumenberg,Marjana Tomic-Canic +6 more
TL;DR: In vivo evidence in VLU patients of pathways that can be targeted in the design of new therapies to promote healing of chronic VLUs is provided, providing mechanistic insight into how the acute healing process can be activated by a cell therapy in chronic nonhealing wounds.
Journal ArticleDOI
Staphylococcus aureus Triggers Induction of miR-15B-5P to Diminish DNA Repair and Deregulate Inflammatory Response in Diabetic Foot Ulcers.
Horacio Ramirez,Irena Pastar,Ivan Jozic,Olivera Stojadinovic,Rivka C. Stone,Nkemcho Ojeh,Joel Gil,Stephen C. Davis,Robert S. Kirsner,Marjana Tomic-Canic +9 more
TL;DR: It is shown that S. aureus inhibits wound closure and induces miR-15b-5p in acute human and porcine wound models and in chronic DFUs, showing a mechanism of inhibition of healing in DFUs previously unreported, to the knowledge.
Journal ArticleDOI
Integrative analysis of miRNA and mRNA paired expression profiling of primary fibroblast derived from diabetic foot ulcers reveals multiple impaired cellular functions.
Liang Liang,Rivka C. Stone,Olivera Stojadinovic,Horacio Ramirez,Horacio Ramirez,Irena Pastar,Anna G. Maione,Avi Smith,Vanessa Yanez,Aristides Veves,Robert S. Kirsner,Jonathan A. Garlick,Marjana Tomic-Canic +12 more
TL;DR: Induction ofmiR‐21‐5p, miR‐34a‐ 5p,MiR‐145‐5P in DFU dermal fibroblasts plays an important role in impairing multiple cellular functions, thus contributing to overall inhibition of healing in DFUs.