Showing papers in "Journal of Investigative Dermatology in 2018"
TL;DR: The tested algorithm performance was comparable to that of 16 dermatologists, and additional images with a broader range of ages and ethnicities should be collected to improve the performance of convolutional neural network.
435 citations
TL;DR: It is shown that there are at least four distinct fibroblast populations in adult human skin, not all of which are spatially segregated, and that ex vivo expansion or in vivo ablation of specific fibro Blast subpopulations may have therapeutic applications in wound healing and diseases characterized by excessive fibrosis.
272 citations
TL;DR: Evidence is provided showing that OPN3 is the key sensor in melanocytes responsible for hyperpigmentation induced by the shorter wavelengths of visible light, and the multimeric tyrosinase/tyrosinases-related protein complex induced after its activation appears as new potential targets for regulating melanogenesis.
200 citations
TL;DR: The complete transcriptome in skin from paired itchy, lesional and nonitchy, nonlesional skin biopsies is analyzed to lead to an increased understanding of the molecular mechanisms of chronic pruritus and provide targets for itch treatment irrespective of disease state.
193 citations
TL;DR: This review synthesizes the main features that render melatonin a promising candidate for the management of several dermatoses associated with substantial oxidative damage and why it promises to be useful in skin cancer prevention, skin photo- and radioprotection, and as an inducer of repair mechanisms that facilitate the recovery of human skin from environmental damage.
175 citations
TL;DR: This concise review of animal models used in wound experiments including mouse, rat, rabbit, pig, and zebrafish are discussed, with a special emphasis on impaired wound healing models.
142 citations
TL;DR: The increased risk of completed suicide among HS patients is not solely explained by lifestyle and demographic differences and the results highlight the profound impact HS has on the lives of patients with this often devastating disease.
136 citations
TL;DR: Open-label studies of ruxolitinib and tofacitinib have shown dramatic clinical responses in moderate to severe AA, providing strong rationale for larger clinical trials using JAK inhibitors in AA.
133 citations
TL;DR: Clinically, Thiamidol visibly reduced the appearance of age spots within 4 weeks, and after 12 weeks some age spots were indistinguishable from the normal adjacent skin.
120 citations
TL;DR: Adult patients with atopic dermatitis who are colonized on their skin with S. aureus have more severe disease, greater type 2 immune deviation, allergen sensitization, barrier disruption, and LDH level elevation than noncolonized patients with AD.
113 citations
TL;DR: How to optimally use TEWL measurements as a skin research tool in vivo and in Vitro is described.
Ludwig Maximilian University of Munich1, University of Marburg2, University of Lübeck3, Keio University4, University of California, Irvine5, University of Groningen6, Emory University7, University Hospital of Bern8, University of Pennsylvania9, University of Modena and Reggio Emilia10, University at Buffalo11, Rabin Medical Center12
TL;DR: This review focuses on the currently existing models of the autoimmune blistering skin disease pemphigus and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantIBody binding.
University of Pennsylvania1, University of California, Los Angeles2, Mayo Clinic3, Duke University4, Stanford University5, University of Texas Southwestern Medical Center6, University of California, San Francisco7, Washington University in St. Louis8, University of Minnesota9, University of California, Davis10, University of Alabama at Birmingham11, Ohio State University12, University of Virginia13, Harvard University14, Brigham and Women's Hospital15, Oregon Health & Science University16, State University of New York System17, University of Utah18, Hofstra University19, University of North Carolina at Chapel Hill20, University of Iowa21, Brown University22
TL;DR: Although the precise role of pharmacotherapy remains unclear, co-administration of corticosteroids and intravenous immunoglobulin, among other therapies, may warrant further study.
TL;DR: Dietary saturated fatty acids are uncovered as major risk factors for the amplification of skin inflammation, independent of obesity-related parameters such as fat mass extension, adipocytokine levels, and glucose homeostasis, and may open new perspectives for adjuvant dietary measures accompanying anti-inflammatory psoriasis therapies in lean and obese patients.
TL;DR: It is indicated that IL-17C is a central mediator of skin inflammation beyond psoriasis and is relevant in particular in AD.
TL;DR: Psoriasis skin and blood have disease-specific phenotype profiles of bioactive LMs represented by omega-6 fatty acid-oxidized derivatives, which provide insights into psoriasis pathophysiology that could potentially contribute to new biomarkers and therapeutics.
TL;DR: Findings identify miR-31 as an important cell-autonomous mediator during the transition from inflammation to re-epithelialization phases of wound healing, suggesting a therapeutic potential for mi R-31 in skin injury repair.
TL;DR: Direct evidence that secreted exosomes exist in human sweat is provided and the proteomic profiling of sweat exosome provides insight into sweat features and the potential physiological significance ofExosomes in immune homeostasis.
TL;DR: The experiments showed an essential role of the NLRP1 rather than theNLRP3 inflammasome in UVB sensing and subsequent IL-1β and -18 secretion by keratinocytes, and the CRISPR/Cas9-targeted cells retained their full differentiation capacity, which might be useful for numerous research and medical applications.
TL;DR: Stratification of tissue responses to T cell activation in resolved lesions could potentially offer individualized prediction of disease relapse during long-term immunomodulatory treatment.
TL;DR: A role for the skin fungus Malassezia in inter-kingdom interactions is defined and it is suggested that this fungus and the enzymes it produces may be beneficial for skin health.
TL;DR: This work demonstrates a mechanism of the antifibrotic effect of DMF via inhibition of Akt1/GSK3β/TAZ/YAP signaling and confirms a critical role of TAZ/ YAP in mediating the profibrotics responses in dermal fibroblasts.
TL;DR: It is shown that S. aureus inhibits wound closure and induces miR-15b-5p in acute human and porcine wound models and in chronic DFUs, showing a mechanism of inhibition of healing in DFUs previously unreported, to the knowledge.
TL;DR: A role for CAV1 down-regulation is suggested in linking the aberrant responsiveness to mechanical stimulation and extracellular matrix accumulation with the progression of keloids, findings that may lead to new developments in the prevention and treatment of keLoid scarring.
TL;DR: The letters "Interpretation of the Outputs of Deep Learning Model trained with Skin Cancer Dataset" and "Automated Dermatological Diagnosis: Hype or Reality?" highlight the opportunities, hurdles, and possible pitfalls with the development of tools that allow for automated skin lesion classification.
TL;DR: Heterozygous mice harboring a CARD14 gain-of-function mutation spontaneously develop a chronic psoriatic phenotype with characteristic scaling skin lesions, epidermal thickening, keratinocyte hyperproliferation, hyperkeratosis, and immune cell infiltration.