Cytochrome P450s (P450s) are subject to inhibition/inactivation by various chemically diverse agents, which may interact directly or indirectly with either the P450 prosthetic heme or the protein moiety or with both moieties. This inhibition is clinically relevant, as it can block physiological pathways as well as result in therapeutically significant beneficial or adverse effects and clinically relevant drug–drug interactions. Herein, we discuss the various chemical agents and their chemical mechanisms that lead to such reversible, quasi-irreversible, or irreversible inhibition of these enzymes. We note that such inhibition targeted at P450-dependent physiological and/or pathological processes has been ingeniously and effectively harnessed not only in the design and development of clinically relevant therapeutic agents but also of fungicides, insecticides, and herbicides.

Inhibition of Cytochrome P450 Enzymes

One stop mycology

N-Heterocyclic derivatives selected from the group consisting of the formulae (I), (II), (III) and (IV): where Z?1, Z2, Z3, R1, R2, R3, R4, R5 and R6? are described herein, are useful as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

N-heterocyclic derivatives as NOS inhibitors

The biosynthesis of steroids and triterpenoids

Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression

Provided is a cosmetic composition, which comprises (A) at least one moisture retaining component selected from the group consisting of amino acids and salts thereof, pyrrolidonecarboxylic acid and salts thereof, lactic acid and salts thereof, urea and betaines; and (B) at least one sesquiterpene alcohol. This cosmetic composition exhibits high effects for alleviating the rough or moisture-lost skin and improving the skin condition such as dry skin or sensitive skin.

Cosmetic use of compositions comprising sesquiterpene alcohol

Inhibition by a novel azole antifungal agent with a geranyl group on lanosterol 14α-demethylase of yeast

Selectivity of isoprenoid-containing imidazole antifungal compounds for sterol 14-demethylase P450 (P45014dm) and 7-ethoxycoumarin O-deethylase P450 of rat liver microsomes

Kosmetische Verwendung von Zusammensetzungen die ein Sesquiterpenalkohol enthalten

A novel process for preparing a 3-phenacylidene phthalide of the general formula (II) ##STR1## which comprises reacting a halogenating reagent with a 2-carboxydibenzoylmethane. The 2-carboxydibenzoylmethane can be inexpensively prepared, so that the 3-phenacylidene phthalides which are useful as a growth regulant for plants and a safering agent to reduce herbicidal injury to plants can be readily obtained economically in high yield.

Hori Kimihiko

Papers

Cosmetic use of compositions comprising sesquiterpene alcohol

Inhibition by a novel azole antifungal agent with a geranyl group on lanosterol 14α-demethylase of yeast

Selectivity of isoprenoid-containing imidazole antifungal compounds for sterol 14-demethylase P450 (P45014dm) and 7-ethoxycoumarin O-deethylase P450 of rat liver microsomes

Kosmetische Verwendung von Zusammensetzungen die ein Sesquiterpenalkohol enthalten

Process for preparing 3-phenacylidene phthalides