Journal ArticleDOI
Selectivity of isoprenoid-containing imidazole antifungal compounds for sterol 14-demethylase P450 (P45014dm) and 7-ethoxycoumarin O-deethylase P450 of rat liver microsomes
Ito Tamami,Aoyama Yuri,Ishida Koichi,Kudoh Michinari,Hori Kimihiko,Tsuchiya Shuichi,Yoshida Yuzo +6 more
TLDR
The results suggest that azole compounds interacting with the side-chain recognition site of P450 14 dm may be good candidates as antifungal agents selective for fungal P45014 dm.About:
This article is published in Biochemical Pharmacology.The article was published on 1994-10-18. It has received 5 citations till now. The article focuses on the topics: Sterol 14-Demethylase & Lanosterol.read more
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Book ChapterDOI
Inhibition of Cytochrome P450 Enzymes
TL;DR: Cytochrome P450s (P450s) are subject to inhibition/inactivation by various chemically diverse agents, which may interact directly or indirectly with either the P450 prosthetic heme or the protein moiety or with both moieties.
Journal ArticleDOI
One stop mycology
TL;DR: This listing covers the period May 1, 1997 through to June 30, 1997, which roughly corresponds with the British Mycological Society's Special Interest Committees.
Journal ArticleDOI
Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression
Heather P. Harding,Yuhong Zhang,Sonya M. Khersonsky,Stefan J. Marciniak,Donalyn Scheuner,Randal J. Kaufman,Norman B. Javitt,Young-Tae Chang,David Ron +8 more
TL;DR: Interestingly, compound-mediated activation of sterol-regulated genes was enhanced in cells with an ISR-blocking mutation in the regulatory phosphorylation site of eIF2alpha, suggesting a mechanism by which interactions between sterol metabolism, the ISR, and the SREBP pathway affect lipid metabolism during ER stress.
Journal ArticleDOI
The amino acid residues affecting the activity and azole susceptibility of rat CYP51 (sterol 14-demethylase P450).
Yuko Nitahara,Kae Kishimoto,Yoshiyasu Yabusaki,Osamu Gotoh,Yuzo Yoshida,Tadao Horiuchi,Yuri Aoyama +6 more
TL;DR: The amino acid residues affecting the function of rat sterol 14-demethylase P450 (CYP51) were examined by means of point mutation, and A144 was identified as a residue affecting the interaction of CYP51 with ketoconazole.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal ArticleDOI
The colorimetric estimation of formaldehyde by means of the Hantzsch reaction
TL;DR: A chronology of key events leading up to and including the birth of Bonnichsen, R. K. & Bonner, J. (1952).
Journal ArticleDOI
Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.
TL;DR: Titration of these purified preparations aerobically with both NADPH and potassium ferricyanide demonstrated unequivocally that the air-stable, reduced form of NADPH-cytochrome c (P-450) reductase contains 2 electron equivalents, confirming recent results obtained.
Journal Article
An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.
W F Greenlee,A Poland +1 more
TL;DR: Kinetic analysis indicated that at least two and possibly more components are involved in the metabolism of 7-ethoxycoumarin and differential stimulation of the maximal activities associated with these components was observed after the administration of phenobarbital, 3-methylcholanthrene, or 2,3,7,8-tetrachlorodibenzo-p-dioxin.