H
Hsiu Kuan Lin
Researcher at National Cheng Kung University
Publications - 5
Citations - 267
Hsiu Kuan Lin is an academic researcher from National Cheng Kung University. The author has contributed to research in topics: Polycystic kidney disease & PKD1. The author has an hindex of 4, co-authored 5 publications receiving 228 citations.
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Journal ArticleDOI
Defining a Link with Autosomal-Dominant Polycystic Kidney Disease in Mice with Congenitally Low Expression of Pkd1
Si Tse Jiang,Yuan Yow Chiou,Ellian Wang,Hsiu Kuan Lin,Yuan Ta Lin,Ying Chih Chi,Chi-Kuang Leo Wang,Ming Jer Tang,Hung Li,Hung Li +9 more
TL;DR: In this viable model, up-regulation of heparin-binding epidermal growth factor-like growth factor accompanied increased epider mal growth factor receptor signaling, which may be involved in abnormal proliferation of the cyst-lining epithelia.
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Targeted disruption of Nphp1 causes male infertility due to defects in the later steps of sperm morphogenesis in mice
Si Tse Jiang,Yuan Yow Chiou,Ellian Wang,Hsiu Kuan Lin,Sue Ping Lee,Hsin Yi Lu,Chi-Kuang Leo Wang,Ming Jer Tang,Hung Li,Hung Li +9 more
TL;DR: Findings indicate that nephrocystin is critically required for the differentiation of early elongating spermatids into spermatozoa in mice, and the possible roles in the formation and maintenance of Sertoli-spermatid junctions are still under investigation.
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The influence of physical and physiological cues on atomic force microscopy-based cell stiffness assessment
TL;DR: The results provide basic and significant information about the suitable selection of physical and physiological cues and show that cell elasticity increases with increasing culture density only in MDCK epithelial cells.
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Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease.
Ellian Wang,Yuan Yow Chiou,Wen Yih Jeng,Hsiu Kuan Lin,Hsi Hui Lin,Hsian Jean Chin,Chi-Kuang Leo Wang,Shang Shiuan Yu,Shih Chieh Tsai,Chih Ying Chiang,Po Hao Cheng,Hong Jie Lin,Si Tse Jiang,Sou Tyau Chiu,Hsiu Mei Hsieh-Li +14 more
TL;DR: In conclusion, overexpression of exogenous kidney-specific Ngal reduced cystic progression and prolonged the lifespan in PKD mice, was associated with reductions in interstitial fibrosis and proliferation, and augmented apoptosis.
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Caveolin-1 down-regulation is required for Wnt5a-Frizzled 2 signalling in Ha-RasV12 -induced cell transformation.
TL;DR: Results suggest that both decreasing Cav1 and increasing exosomal Wnt5a must be implemented during Ha‐RasV12‐driven cell transformation, and suggest that Cav1‐dependent repression of Fzd2 and exosome uptake is potentially relevant to its antitransformation activity.