Since PTP1B enzyme was discovered in 1988, it has captured the research community's attention. This landmark discovery has stimulated numerous research studies on a variety of human diseases, including cancer, inflammation, and diabetes. Tremendous progress has been made in finding PTP1B inhibitors and exploring PTP1B regulatory mechanisms. This review investigates for the natural PTP1B inhibitors, and focuses on the common characteristics of the discovered structures and structure-activity relationships. To facilitate understanding, all the natural compounds are here divided into five different classes (fatty acids, phenolics, terpenoids, steroids, and alkaloids), according to their skeletons. These PTP1B inhibitors of scaffold structures could serve as a theoretical basis for new concept drug discovery and design.

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Protein tyrosine phosphatase 1B inhibitors from natural sources.

1-Isoindolinone scaffold-based natural products with a promising diverse bioactivity.

Alkaloids from aerial parts of Houttuynia cordata and their anti-inflammatory activity.

Recent updates on development of protein-tyrosine phosphatase 1B inhibitors for treatment of diabetes, obesity and related disorders.

The effect of fishwort (Houttuynia cordata) on skin mucosal, serum immunities, and growth performance of Nile tilapia.

Bioactive alkaloids from the aerial parts of Houttuynia cordata.

The invention discloses a traditional Chinese medicine healthcare insole and a preparation method thereof. The traditional Chinese healthcare insole comprises an upper layer, a middle layer and a lower layer. The middle layer is a traditional Chinese medicine layer, and the traditional Chinese medicine layer is prepared from, by weight, 5-13 parts of fructus kochiae, 4-15 parts of fructus cnidii, 4-12 parts of cortex dictamni, 3-13 parts of radix angelicae dahuricae, 5-16 parts of cortex phellodendri, 4-17 parts of Chinese honeylocust fruits, 3-14 parts of cortex meliae, 4-13 parts of golden larch bark, 3-9 parts of rheum officinale, 4-13 parts of sophora flavescens, 3-10 parts of saposhnicovia divaricata, 4-11 parts of lithospermum, 2-10 parts of asarum, 4-15 parts of angelica sinensis, 4-11 parts of cloves and 5-12 parts of ligusticum wallichii. The traditional Chinese medicine is sandwiched in the middle of the traditional Chinese medicine healthcare insole and is pure natural Chinese herbal medicine, the preparation method is simple, cleaning is convenient, raw materials are saved, and the insole has the healthcare functions of fighting bacteria and diminishing inflammation, promoting blood circulation to arrest pain, clearing away heat and toxic materials, relieving itching and treating tinea and the like, and further has the functions of absorbing sweat, conducting deodorization, killing bacteria and preventing dermatophytosis.

Traditional Chinese medicine healthcare insole and preparation method thereof

The invention relates to flavones separated and purified from shepherd's purse. The method comprises the following steps: ethanol ultrasonic extraction, solvent extraction, silica gel column chromatography eluting separation, resin column adsorption, silica gel column chromatography eluting separation, vacuum concentration, vacuum drying and the like. The name of the separated flavones is 2-(3,4-dimethoxyphenyl)-5-(hydroxymethyl-7-O-beta-D-glucosyl-4H-chromene-4-one. The raw material, which is the medicinal and edible shepherd's purse, has abundant sources and is cheap and accessible. The prepared 5-hydroxymethyl new flavones have novel structure, have obvious effect of inhibiting tumor cell proliferation, and can be used as a cell proliferation inhibitor or antitumor agent for antitumor research. The flavones have favorable development and utilization values, and lay foundation for research and development of clinical drugs for preventing and treating tumors in future.

Flavones separated and purified from shepherd's purse, and preparation method and application thereof

The invention discloses a naringenin carbamate compound, a preparation method and an application thereof, wherein the naringenin carbamate compound is characterized in that a chemical structure formula is represented as the formula (I); the naringenin carbamate compound can be used for preparing medicines for treating and/or preventing neurodegenerative diseases.

Huang Hongchun

Papers

Bioactive alkaloids from the aerial parts of Houttuynia cordata.

Traditional Chinese medicine healthcare insole and preparation method thereof

Flavones separated and purified from shepherd's purse, and preparation method and application thereof

Naringenin carbamate compound, preparation method and application thereof