H
Hui Cang
Researcher at Shanghai Jiao Tong University
Publications - 14
Citations - 1041
Hui Cang is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Adipogenesis & SUMO protein. The author has an hindex of 11, co-authored 11 publications receiving 929 citations.
Papers
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Journal ArticleDOI
SENP3 is responsible for HIF‐1 transactivation under mild oxidative stress via p300 de‐SUMOylation
Chao Huang,Yan Han,Yumei Wang,Xuxu Sun,Shan Yan,Edward T.H. Yeh,Yuying Chen,Hui Cang,Hui Li,Guiying Shi,Jinke Cheng,Xueming Tang,Jing Yi +12 more
TL;DR: SENP3 is identified as a redox sensor that regulates HIF‐1 transcriptional activity under oxidative stress through the de‐SUMOylation of p300.
Journal Article
Detection of aberrant p16 methylation in the serum of colorectal cancer patients.
Hongzhi Zou,Bao-Ming Yu,Zhi-Wei Wang,Ji-Yuan Sun,Hui Cang,Fei Gao,Dong Hua Li,Ren Zhao,Guo-Guang Feng,Jing Yi +9 more
TL;DR: This assay offers a potential means for the serum-based detection and/or monitoring of CRC patients and was significantly associated with later Dukes' stage according to clinicopathological characteristics.
Journal Article
Detection of aberrant p16 methylation in the serum of colorectal cancer patients.
TL;DR: In this paper, the p16 promoter methylation in colorectal cancer (CRC) was detected in serum of 34 patients with adenomatous polyps and 10 healthy individuals, and the association of p16 hypermethylation in serum DNA with clinicopathological characteristics was analyzed.
Journal ArticleDOI
Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90
Shan Yan,Xuxu Sun,Binggang Xiang,Hui Cang,Xunlei Kang,Yuying Chen,Hui Li,Guiying Shi,Edward T.H. Yeh,Beilei Wang,Xiangrui Wang,Jing Yi +11 more
TL;DR: It is demonstrated for the first time that CHIP and Hsp90 interplay with a client alternately under non‐stress and stress conditions, and the choice between stabilization and degradation is made by the redox state of the client.
Journal ArticleDOI
Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1.
TL;DR: In this article, the authors investigated the molecular mechanisms by which ROS mediates caspase-9 activation and showed that the cellular oxidative state facilitates casp-9 activations and activation in mitochondria.