H
Hui Li
Researcher at China Pharmaceutical University
Publications - 19
Citations - 167
Hui Li is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: Cell growth & Myeloid leukemia. The author has an hindex of 6, co-authored 16 publications receiving 75 citations.
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Journal ArticleDOI
Natural HDAC‐1/8 inhibitor baicalein exerts therapeutic effect in CBF‐AML
Xiaoxuan Yu,Xiaoxuan Yu,Hui Li,Po Hu,Yingjie Qing,Xiangyuan Wang,Mengyuan Zhu,Hongzheng Wang,Zhanyu Wang,Jingyan Xu,Qinglong Guo,Hui Hui +11 more
TL;DR: Findings improved the understanding of the epigenetic regulation of Baicalein, and warrant therapeutic potential of Baicalsein for CBF‐AML.
Journal ArticleDOI
PLSCR1/IP3R1/Ca 2+ axis contributes to differentiation of primary AML cells induced by wogonoside.
Hui Li,Jingyan Xu,Yuxin Zhou,Xiao Liu,Le Shen,Yichao Zhu,Zhiyu Li,Xiaotang Wang,Qinglong Guo,Hui Hui +9 more
TL;DR: It is reported that wogonoside promotes the expression of PLSCR1 and enhances its nuclear translocation and binding to the 1, 4, 5-trisphosphate receptor 1 (IP3R1) promoter in AML patient-derived primary cells.
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Wogonoside induces growth inhibition and cell cycle arrest via promoting the expression and binding activity of GATA-1 in chronic myelogenous leukemia cells
Hui Li,Hui Hui,Jingyan Xu,Hao Yang,Xiaoxiao Zhang,Xiao Liu,Yuxin Zhou,Zhiyu Li,Qinglong Guo,Na Lu +9 more
TL;DR: In vivo studies showed that administration of wogonoside decreased CML cells and prolonged survival in NOD/SCID mice with CML cell xenografts, suggesting that wogonside may act as a promising drug for the treatment of imatinib-resistant CML.
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Oroxylin A, a natural anticancer flavonoid compound, induces differentiation of t(8;21)-positive Kasumi-1 and primary acute myeloid leukemia cells
TL;DR: In vivo study indicated that OA could prolong the survival of AML-bearing NOD/SCID mice and reduce leukocytic infiltration of the spleen and the mechanism required further investigation.
Journal ArticleDOI
Involvement of p53 Acetylation in Growth Suppression of Cutaneous T-Cell Lymphomas Induced by HDAC Inhibition.
Xiaoxuan Yu,Hui Li,Mengyuan Zhu,Po Hu,Xiao Liu,Yingjie Qing,Xiangyuan Wang,Hongzheng Wang,Zhanyu Wang,Jingyan Xu,Renxiang Tan,Qinglong Guo,Hui Hui +12 more
TL;DR: Baicalein, a natural product, provides a potential and safe natural HDAC inhibitor for the treatment of CTCLs and indicates a special mechanism of HDAC-1/8 and p53 in T-cell lymphoma cells.