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Yingjie Qing

Researcher at China Pharmaceutical University

Publications -  13
Citations -  93

Yingjie Qing is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: Apoptosis & Lysosome. The author has an hindex of 3, co-authored 10 publications receiving 25 citations.

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Natural HDAC‐1/8 inhibitor baicalein exerts therapeutic effect in CBF‐AML

Xiaoxuan Yu, +11 more
- 01 Aug 2020 - 
TL;DR: Findings improved the understanding of the epigenetic regulation of Baicalein, and warrant therapeutic potential of Baicalsein for CBF‐AML.
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Involvement of p53 Acetylation in Growth Suppression of Cutaneous T-Cell Lymphomas Induced by HDAC Inhibition.

Xiaoxuan Yu, +12 more
- 01 Oct 2020 - 
TL;DR: Baicalein, a natural product, provides a potential and safe natural HDAC inhibitor for the treatment of CTCLs and indicates a special mechanism of HDAC-1/8 and p53 in T-cell lymphoma cells.
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Mitotic catastrophe and p53-dependent senescence induction in T-cell malignancies exposed to nonlethal dosage of GL-V9

Hui Li, +11 more
- 01 Jan 2020 - 
TL;DR: The study showed that nonlethal dosage of GL-V9, a potential anticancer drug, not only attenuated cell growth and survival, but also arrested the cell cycle in G2/M phase and induced multipolar spindles, nuclear alterations, which are the most prominent morphological characteristics of mitotic catastrophe, in T-cell malignancies cell lines including Jurkat,HuT-102, and HuT-78.
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FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation.

Po Hu, +9 more
- 13 Jan 2021 - 
TL;DR: In this article, a synthetic flavonoid compound, FV-429, inhibited autophagy flux, promoted autophagosomes accumulation, and inhibited lysosomal degradation in T-cell malignancies.
Journal ArticleDOI

One-Two Punch Therapy for the Treatment of T-Cell Malignancies Involving p53-Dependent Cellular Senescence.

Yingjie Qing, +11 more
- 01 Jan 2021 - 
TL;DR: Wogonin-induced cellular senescence provides a permanent cell cycle arrest during tumorigenesis and cancer development, particularly when combined with senolytics to promote apoptosis of senescent cells, which is an innovation for cancer therapy.