Hwa-Ying Wang

TL;DR: It is demonstrated that specific genetic markers, that have been associated with increased IL-1 production, are a strong indicator of susceptibility to severe periodontitis in adults.

TL;DR: This study demonstrates that the composite IL-1 genotype is significantly associated with the severity of adult periodontitis and confirmed that both IL- 1 genotyping and smoking history provide objective risk factors for periodontal disease in a private practice environment.

TL;DR: Findings from this study bring into question the usefulness of the composite genotype of allele 2 of both IL-1A +4845 andIL-1B +3954 as a method for determining the susceptibility of Chinese patients to adult periodontitis.

TL;DR: It is suggested that bisphosphonate treatment improves the clinical outcome of non-surgical periodontal therapy and may be an appropriate adjunctive treatment to preserveperiodontal bone mass.

TL;DR: This is the first demonstration of a relationship between in vivo levels of an inflammatory mediator and gene promoter haplotypes on both chromosomes and these findings may apply to other inducible genes and could provide a logical framework for exploring disease risk related to genetic variability in pathogenic mediators.