J
John J. Rogus
Researcher at Joslin Diabetes Center
Publications - 46
Citations - 2624
John J. Rogus is an academic researcher from Joslin Diabetes Center. The author has contributed to research in topics: Population & Diabetic nephropathy. The author has an hindex of 26, co-authored 46 publications receiving 2522 citations. Previous affiliations of John J. Rogus include University of Ioannina & Harvard University.
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Journal ArticleDOI
Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context
Hongmin Chen,Leon Wilkins,Nazneen Aziz,Chris Cannings,David H. Wyllie,Colin D. Bingle,John J. Rogus,James D. Beck,Steven Offenbacher,Michael J. Cork,Maryam Rafie-Kolpin,Chung-Ming Hsieh,Kenneth S. Kornman,Gordon W. Duff +13 more
TL;DR: The four haplotypes that showed different contextual effects on SNP function accounted for >98% of the estimated haplotypes in Caucasian and African-American populations, which underlines the importance of understanding the haplotype structure of populations used for genetic studies.
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Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes
Marcus G. Pezzolesi,G. David Poznik,Josyf C. Mychaleckyj,Andrew D. Paterson,Michelle T. Barati,Jon B. Klein,Daniel P.K. Ng,Grzegorz Placha,Luis Henrique Santos Canani,Jacek Bochenski,Daryl Waggott,Michael L. Merchant,Bozena Krolewski,Lucia Mirea,Krzysztof Wanic,Pisut Katavetin,Masahiko Kure,Paweł Wołkow,Jonathon Dunn,Adam M. Smiles,William H. Walker,Andrew P. Boright,Shelley B. Bull,Alessandro Doria,John J. Rogus,Stephen S. Rich,James H. Warram,Andrzej S. Krolewski +27 more
TL;DR: Genetic associations for susceptibility to diabetic nephropathy are identified at two novel candidate loci near the FRMD3 and CARS genes, which implicates previously unsuspected pathways in the pathogenesis of this important late complication of type 1 diabetes.
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Epidemic of end-stage renal disease in people with diabetes in the United States population: do we know the cause?
Camille A. Jones,Andrzej S. Krolewski,John J. Rogus,Jay L. Xue,Allan Collins,James H. Warram +5 more
TL;DR: It is hypothesized that an epidemic of end-stage renal diseae (ESRD) has occurred in people with diabetes in the United States population over the last two decades and, therefore, qualifies as an epidemic.
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An extreme-sib-pair genome scan for genes regulating blood pressure.
Xiping Xu,Xiping Xu,Xiping Xu,John J. Rogus,Henry Terwedow,Jianhua Yang,Zhaoxi Wang,Zhaoxi Wang,Changzhong Chen,Changzhong Chen,Tianhua Niu,Binyan Wang,Hengqiu Xu,Scott T. Weiss,Nicholas J. Schork,Nicholas J. Schork,Zhian Fang +16 more
TL;DR: This study's study population, selected from a blood-pressure screen of >200,000 Chinese adults, comprises rare but highly efficient extreme sib pairs and all but a single parent of these sibs, representing one of the most powerful of its kind.
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Major susceptibility locus for nephropathy in type 1 diabetes on chromosome 3q: results of novel discordant sib-pair analysis.
TL;DR: This study provides very strong evidence that a 20-cM region around AT1 contains a major locus for susceptibility to DN, and does not implicate AT1 itself in the etiology of DN.