H
Hyun-Ju Park
Researcher at Sungkyunkwan University
Publications - 106
Citations - 1600
Hyun-Ju Park is an academic researcher from Sungkyunkwan University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 19, co-authored 93 publications receiving 1247 citations. Previous affiliations of Hyun-Ju Park include Korea Institute of Science and Technology.
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Journal ArticleDOI
Identification of RNA pseudoknot-binding ligand that inhibits the -1 ribosomal frameshifting of SARS-coronavirus by structure-based virtual screening.
TL;DR: A novel ligand 43 that dramatically inhibits the -1 RF of SARS-CoV is successfully identified and is an interesting lead for the design of novel antiviral agents against SARS -CoV.
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A 30-year Trend Analysis in the Epidemiology of Inflammatory Bowel Disease in the Songpa-Kangdong District of Seoul, Korea in 1986–2015
Sang Hyoung Park,Ye-Jee Kim,Kyoung Hoon Rhee,Young-Ho Kim,Sung Noh Hong,Kyung Ho Kim,Seung In Seo,Jae Myung Cha,Sun Yong Park,Seung Kyu Jeong,Ji Hyun Lee,Hyun-Ju Park,Joo Sung Kim,Jong Pil Im,Hyuk Yoon,Sunghoon Kim,Jisun Jang,Jeong Hwan Kim,Seong O Suh,Young Kyun Kim,Byong Duk Ye,Suk-Kyun Yang +21 more
TL;DR: The incidence and prevalence of IBD in Korea have continued to increase over the past three decades and Korean patients have distinct demographic and phenotypic characteristics including a male predominance and high frequency of perianal fistula/abscess in CD and high proportion of proctitis in UC.
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Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin- 2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): A highly potent, selective, and orally bioavailable inhibitor of TGF-β type I receptor kinase as cancer immunotherapeutic/antifibrotic agent
Cheng Hua Jin,Maddeboina Krishnaiah,Domalapally Sreenu,Vura Bala Subrahmanyam,Kota S Rao,Hwa Jeong Lee,So-Jung Park,Hyun-Ju Park,Kiho Lee,Yhun Yhong Sheen,Dae-Kee Kim +10 more
TL;DR: Rational optimization of 6 has led to the identification of a highly potent, selective, and orally bioavailable ALK5 inhibitor 12b, and selectivity profiling of 12b using a panel of 320 protein kinases revealed that it is a highly selective ALK 5/ALK4 inhibitor.
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G-Quadruplex Binding Ligands: from Naturally Occurring to Rationally Designed Molecules
TL;DR: The key structural motifs of G-quadruplex binding ligands, that is, an aromatic core and basic side chains, are addressed in the context of how these molecules interact with G- quadruplex.
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Novel Molecular Mechanism for Actinomycin D Activity as an Oncogenic Promoter G-Quadruplex Binder
Hyun-Jin Kang,Hyun-Ju Park +1 more
TL;DR: A novel mechanism underlying the anticancer activity of ActD is revealed, whereby ActD interacts with oncogenic promoter G-quadruplex DNA to repress gene expression.